An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies

The pH-selective interaction between the immunoglobulin G (IgG) fragment crystallizable region (Fc region) and the neonatal Fc receptor (FcRn) is critical for prolonging the circulating half-lives of IgG molecules through intracellular trafficking and recycling. By using directed evolution, we succe...

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Detalles Bibliográficos
Autores principales: Ko, Sanghwan, Park, Sora, Sohn, Myung Ho, Jo, Migyeong, Ko, Byoung Joon, Na, Jung-Hyun, Yoo, Hojin, Jeong, Ae Lee, Ha, Kyungsoo, Woo, Ju Rang, Lim, Chungsu, Shin, Jung Hyu, Lee, Dohyun, Choi, So-Young, Jung, Sang Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628495/
https://www.ncbi.nlm.nih.gov/pubmed/36319752
http://dx.doi.org/10.1038/s12276-022-00870-5

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