Clonal hematopoiesis, multi-omics and coronary artery disease

Studies of the genetic architecture of cardiovascular disease once focused on heritable germline factors. Newer work has shed light on the role of somatic mutations in blood cells. These mechanistic and multi-omics studies, along with phenotypic analyses, offer the prospect of new precision cardiova...

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Detalles Bibliográficos
Autores principales: Nakao, Tetsushi, Natarajan, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628526/
https://www.ncbi.nlm.nih.gov/pubmed/36339018
http://dx.doi.org/10.1038/s44161-022-00154-1
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author Nakao, Tetsushi
Natarajan, Pradeep
author_facet Nakao, Tetsushi
Natarajan, Pradeep
author_sort Nakao, Tetsushi
collection PubMed
description Studies of the genetic architecture of cardiovascular disease once focused on heritable germline factors. Newer work has shed light on the role of somatic mutations in blood cells. These mechanistic and multi-omics studies, along with phenotypic analyses, offer the prospect of new precision cardiovascular medicine paradigms.
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spelling pubmed-96285262022-11-02 Clonal hematopoiesis, multi-omics and coronary artery disease Nakao, Tetsushi Natarajan, Pradeep Nat Cardiovasc Res Comment Studies of the genetic architecture of cardiovascular disease once focused on heritable germline factors. Newer work has shed light on the role of somatic mutations in blood cells. These mechanistic and multi-omics studies, along with phenotypic analyses, offer the prospect of new precision cardiovascular medicine paradigms. Nature Publishing Group UK 2022-11-02 2022 /pmc/articles/PMC9628526/ /pubmed/36339018 http://dx.doi.org/10.1038/s44161-022-00154-1 Text en © Springer Nature Limited 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Nakao, Tetsushi
Natarajan, Pradeep
Clonal hematopoiesis, multi-omics and coronary artery disease
title Clonal hematopoiesis, multi-omics and coronary artery disease
title_full Clonal hematopoiesis, multi-omics and coronary artery disease
title_fullStr Clonal hematopoiesis, multi-omics and coronary artery disease
title_full_unstemmed Clonal hematopoiesis, multi-omics and coronary artery disease
title_short Clonal hematopoiesis, multi-omics and coronary artery disease
title_sort clonal hematopoiesis, multi-omics and coronary artery disease
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628526/
https://www.ncbi.nlm.nih.gov/pubmed/36339018
http://dx.doi.org/10.1038/s44161-022-00154-1
work_keys_str_mv AT nakaotetsushi clonalhematopoiesismultiomicsandcoronaryarterydisease
AT natarajanpradeep clonalhematopoiesismultiomicsandcoronaryarterydisease

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