ODP571 Blockade of ErbB-2 Nuclear Function Induces the Interferon Signaling Pathway in Breast Cancer Models Resistant to Trastuzumab

ErbB-2, a member of ErbB family of receptor tyrosine kinases, is a key oncogenic driver in breast cancer. Despite clinical efficiency of ErbB-2-targeted therapies (trastuzumab, TZ), resistance to drugs is a major issue in the clinic. While ErbB-2 is mainly a plasma membrane-bound receptor, it also m...

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Detalles Bibliográficos
Autores principales: Elizalde, Patricia V, Cordo Russo, Rosalia, Madera, Santiago, Merin, Sharon S, Chervo, María F, Ebrahimie, Esmaeil, Selth, Luke, Chiauzzi, Violeta A, Dupont, Agustina, Barchuk, Sabrina, Figurelli, Silvina, Lopez Della Vecchia, Daniel, Guzmán, Pablo, Roa, Juan C, Levit, Claudio, Lebersztein, Gabriel, Anfuso, Fabiana, Proietti, Cecilia J, Schillaci, Roxana, Hickey, Theresa E, Tilley, Wayne D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628591/
http://dx.doi.org/10.1210/jendso/bvac150.1817

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