Adaptive single-KIR(+)NKG2C(+) NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia

BACKGROUND: Natural killer (NK) cells hold great promise as a source for allogeneic cell therapy against hematological malignancies, including acute myeloid leukemia (AML). Current treatments are hampered by variability in NK cell subset responses, a limitation which could be circumvented by specifi...

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Detalles Bibliográficos
Autores principales: Haroun-Izquierdo, Alvaro, Vincenti, Marianna, Netskar, Herman, van Ooijen, Hanna, Zhang, Bin, Bendzick, Laura, Kanaya, Minoru, Momayyezi, Pouria, Li, Shuo, Wiiger, Merete Thune, Hoel, Hanna Julie, Krokeide, Silje Zandstra, Kremer, Veronika, Tjonnfjord, Geir, Berggren, Stéphanie, Wikström, Kristina, Blomberg, Pontus, Alici, Evren, Felices, Martin, Önfelt, Björn, Höglund, Petter, Valamehr, Bahram, Ljunggren, Hans-Gustaf, Björklund, Andreas, Hammer, Quirin, Kveberg, Lise, Cichocki, Frank, Miller, Jeffrey S, Malmberg, Karl-Johan, Sohlberg, Ebba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628692/
https://www.ncbi.nlm.nih.gov/pubmed/36319065
http://dx.doi.org/10.1136/jitc-2022-005577

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