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Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer
INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously e...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Urological Association
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628729/ https://www.ncbi.nlm.nih.gov/pubmed/36381153 http://dx.doi.org/10.5173/ceju.2022.0053 |
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author | Flammia, Rocco Simone Chierigo, Francesco Würnschimmel, Christoph Wenzel, Mike Horlemann, Benedikt Tian, Zhen Borghesi, Marco Leonardo, Costantino Tilki, Derya Shariat, Shahrokh F. Anceschi, Umberto Chun, Felix K.H. Terrone, Carlo Saad, Fred Gallucci, Michele Karakiewicz, Pierre I. |
author_facet | Flammia, Rocco Simone Chierigo, Francesco Würnschimmel, Christoph Wenzel, Mike Horlemann, Benedikt Tian, Zhen Borghesi, Marco Leonardo, Costantino Tilki, Derya Shariat, Shahrokh F. Anceschi, Umberto Chun, Felix K.H. Terrone, Carlo Saad, Fred Gallucci, Michele Karakiewicz, Pierre I. |
author_sort | Flammia, Rocco Simone |
collection | PubMed |
description | INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously examined in VH NMIBC. Our aim was to test the effect of female sex on stage at presentation and CSM in VH NMIBC. MATERIAL AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016), we identified patients aged ≥18 years, with histologically confirmed VH NMIBC. Logistic regression models addressed T1 stage at diagnosis after multivariable adjustments for tumor grade, age and race/ethnicity. Before Kaplan-Meier plots and Cox regression analyses, propensity score matched adjusting for histological variants, T-stage, tumor grade, age and race/ethnicity was performed. RESULTS: Overall, 2,205 VH NMIBC patients were identified. Of those, 28% (n = 607) were female. Females were older (77 vs 74 years, p <0.001) and more frequently harbored T1 stage (55 vs 45%, p <0.001). Female sex independently predicted T1 stage (odds ratio [OR] = 1.66, 95% Confidence Interval [CI] = 1.35−2.03, p <0.001). Female sex also exhibited higher CSM, after matching for all assessable variables, including stage (hazard ratio [HR] = 1.91, 95% CI = 1.45–2.54, p <0.001). CONCLUSIONS: In VH NMIBC, female sex is an indicator of higher rate of T1 stage and, fully independently of stage, female sex also results in higher CSM. |
format | Online Article Text |
id | pubmed-9628729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Polish Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-96287292022-11-14 Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer Flammia, Rocco Simone Chierigo, Francesco Würnschimmel, Christoph Wenzel, Mike Horlemann, Benedikt Tian, Zhen Borghesi, Marco Leonardo, Costantino Tilki, Derya Shariat, Shahrokh F. Anceschi, Umberto Chun, Felix K.H. Terrone, Carlo Saad, Fred Gallucci, Michele Karakiewicz, Pierre I. Cent European J Urol Original Paper INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously examined in VH NMIBC. Our aim was to test the effect of female sex on stage at presentation and CSM in VH NMIBC. MATERIAL AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016), we identified patients aged ≥18 years, with histologically confirmed VH NMIBC. Logistic regression models addressed T1 stage at diagnosis after multivariable adjustments for tumor grade, age and race/ethnicity. Before Kaplan-Meier plots and Cox regression analyses, propensity score matched adjusting for histological variants, T-stage, tumor grade, age and race/ethnicity was performed. RESULTS: Overall, 2,205 VH NMIBC patients were identified. Of those, 28% (n = 607) were female. Females were older (77 vs 74 years, p <0.001) and more frequently harbored T1 stage (55 vs 45%, p <0.001). Female sex independently predicted T1 stage (odds ratio [OR] = 1.66, 95% Confidence Interval [CI] = 1.35−2.03, p <0.001). Female sex also exhibited higher CSM, after matching for all assessable variables, including stage (hazard ratio [HR] = 1.91, 95% CI = 1.45–2.54, p <0.001). CONCLUSIONS: In VH NMIBC, female sex is an indicator of higher rate of T1 stage and, fully independently of stage, female sex also results in higher CSM. Polish Urological Association 2022-07-18 2022 /pmc/articles/PMC9628729/ /pubmed/36381153 http://dx.doi.org/10.5173/ceju.2022.0053 Text en Copyright by Polish Urological Association https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Flammia, Rocco Simone Chierigo, Francesco Würnschimmel, Christoph Wenzel, Mike Horlemann, Benedikt Tian, Zhen Borghesi, Marco Leonardo, Costantino Tilki, Derya Shariat, Shahrokh F. Anceschi, Umberto Chun, Felix K.H. Terrone, Carlo Saad, Fred Gallucci, Michele Karakiewicz, Pierre I. Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer |
title | Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer |
title_full | Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer |
title_fullStr | Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer |
title_full_unstemmed | Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer |
title_short | Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer |
title_sort | sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628729/ https://www.ncbi.nlm.nih.gov/pubmed/36381153 http://dx.doi.org/10.5173/ceju.2022.0053 |
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