Cargando…

Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer

INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously e...

Descripción completa

Detalles Bibliográficos
Autores principales: Flammia, Rocco Simone, Chierigo, Francesco, Würnschimmel, Christoph, Wenzel, Mike, Horlemann, Benedikt, Tian, Zhen, Borghesi, Marco, Leonardo, Costantino, Tilki, Derya, Shariat, Shahrokh F., Anceschi, Umberto, Chun, Felix K.H., Terrone, Carlo, Saad, Fred, Gallucci, Michele, Karakiewicz, Pierre I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Urological Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628729/
https://www.ncbi.nlm.nih.gov/pubmed/36381153
http://dx.doi.org/10.5173/ceju.2022.0053
_version_ 1784823250315902976
author Flammia, Rocco Simone
Chierigo, Francesco
Würnschimmel, Christoph
Wenzel, Mike
Horlemann, Benedikt
Tian, Zhen
Borghesi, Marco
Leonardo, Costantino
Tilki, Derya
Shariat, Shahrokh F.
Anceschi, Umberto
Chun, Felix K.H.
Terrone, Carlo
Saad, Fred
Gallucci, Michele
Karakiewicz, Pierre I.
author_facet Flammia, Rocco Simone
Chierigo, Francesco
Würnschimmel, Christoph
Wenzel, Mike
Horlemann, Benedikt
Tian, Zhen
Borghesi, Marco
Leonardo, Costantino
Tilki, Derya
Shariat, Shahrokh F.
Anceschi, Umberto
Chun, Felix K.H.
Terrone, Carlo
Saad, Fred
Gallucci, Michele
Karakiewicz, Pierre I.
author_sort Flammia, Rocco Simone
collection PubMed
description INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously examined in VH NMIBC. Our aim was to test the effect of female sex on stage at presentation and CSM in VH NMIBC. MATERIAL AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016), we identified patients aged ≥18 years, with histologically confirmed VH NMIBC. Logistic regression models addressed T1 stage at diagnosis after multivariable adjustments for tumor grade, age and race/ethnicity. Before Kaplan-Meier plots and Cox regression analyses, propensity score matched adjusting for histological variants, T-stage, tumor grade, age and race/ethnicity was performed. RESULTS: Overall, 2,205 VH NMIBC patients were identified. Of those, 28% (n = 607) were female. Females were older (77 vs 74 years, p <0.001) and more frequently harbored T1 stage (55 vs 45%, p <0.001). Female sex independently predicted T1 stage (odds ratio [OR] = 1.66, 95% Confidence Interval [CI] = 1.35−2.03, p <0.001). Female sex also exhibited higher CSM, after matching for all assessable variables, including stage (hazard ratio [HR] = 1.91, 95% CI = 1.45–2.54, p <0.001). CONCLUSIONS: In VH NMIBC, female sex is an indicator of higher rate of T1 stage and, fully independently of stage, female sex also results in higher CSM.
format Online
Article
Text
id pubmed-9628729
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Polish Urological Association
record_format MEDLINE/PubMed
spelling pubmed-96287292022-11-14 Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer Flammia, Rocco Simone Chierigo, Francesco Würnschimmel, Christoph Wenzel, Mike Horlemann, Benedikt Tian, Zhen Borghesi, Marco Leonardo, Costantino Tilki, Derya Shariat, Shahrokh F. Anceschi, Umberto Chun, Felix K.H. Terrone, Carlo Saad, Fred Gallucci, Michele Karakiewicz, Pierre I. Cent European J Urol Original Paper INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously examined in VH NMIBC. Our aim was to test the effect of female sex on stage at presentation and CSM in VH NMIBC. MATERIAL AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016), we identified patients aged ≥18 years, with histologically confirmed VH NMIBC. Logistic regression models addressed T1 stage at diagnosis after multivariable adjustments for tumor grade, age and race/ethnicity. Before Kaplan-Meier plots and Cox regression analyses, propensity score matched adjusting for histological variants, T-stage, tumor grade, age and race/ethnicity was performed. RESULTS: Overall, 2,205 VH NMIBC patients were identified. Of those, 28% (n = 607) were female. Females were older (77 vs 74 years, p <0.001) and more frequently harbored T1 stage (55 vs 45%, p <0.001). Female sex independently predicted T1 stage (odds ratio [OR] = 1.66, 95% Confidence Interval [CI] = 1.35−2.03, p <0.001). Female sex also exhibited higher CSM, after matching for all assessable variables, including stage (hazard ratio [HR] = 1.91, 95% CI = 1.45–2.54, p <0.001). CONCLUSIONS: In VH NMIBC, female sex is an indicator of higher rate of T1 stage and, fully independently of stage, female sex also results in higher CSM. Polish Urological Association 2022-07-18 2022 /pmc/articles/PMC9628729/ /pubmed/36381153 http://dx.doi.org/10.5173/ceju.2022.0053 Text en Copyright by Polish Urological Association https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Flammia, Rocco Simone
Chierigo, Francesco
Würnschimmel, Christoph
Wenzel, Mike
Horlemann, Benedikt
Tian, Zhen
Borghesi, Marco
Leonardo, Costantino
Tilki, Derya
Shariat, Shahrokh F.
Anceschi, Umberto
Chun, Felix K.H.
Terrone, Carlo
Saad, Fred
Gallucci, Michele
Karakiewicz, Pierre I.
Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer
title Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer
title_full Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer
title_fullStr Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer
title_full_unstemmed Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer
title_short Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer
title_sort sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628729/
https://www.ncbi.nlm.nih.gov/pubmed/36381153
http://dx.doi.org/10.5173/ceju.2022.0053
work_keys_str_mv AT flammiaroccosimone sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT chierigofrancesco sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT wurnschimmelchristoph sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT wenzelmike sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT horlemannbenedikt sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT tianzhen sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT borghesimarco sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT leonardocostantino sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT tilkiderya sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT shariatshahrokhf sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT anceschiumberto sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT chunfelixkh sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT terronecarlo sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT saadfred sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT galluccimichele sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer
AT karakiewiczpierrei sexrelateddifferencesinnonurothelialvarianthistologynonmuscleinvasivebladdercancer