LBODP106 Multi-omics Analyses Of MEN1 Missense Mutations Identify Disruption Of Menin-MLL And Menin-JunD Interactions As Critical Requirements For Molecular Pathogenicity

Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 endocrine tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other types of cancers. The MEN1 gene product, menin, is involved in transcriptional an...

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Detalles Bibliográficos
Autores principales: Dreijerink, Koen Marie Anton, Ozyerli-Goknar, Ezgi, Koidl, Stefanie, Van der Lelij, Ewoud, Van den Heuvel, Priscilla, Kooijman, Jeffrey, Biniossek, Martin, Rodenburg, Kees, Nizamuddin, Sheikh, Timmers, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628758/
http://dx.doi.org/10.1210/jendso/bvac150.1788

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