RF07 | PSUN384 Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with a 18% 5-year survival rate. Mice lacking the splicing factor SRSF3 in hepatocytes (SKO mice) overexpress IGF2 and are predisposed to developing HCC with age. Loss of Igf2 in the SKO background prevented hepatic fibrosis an...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Manasi, Ellies, Lesley, Jih, Lily, Kumar, Deepak, Oberg, Alexis, Sahoo, Debashis, Sauceda, Consuelo, Webster, Prof Nicholas, Wu, Panyisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628777/
http://dx.doi.org/10.1210/jendso/bvac150.1857

Ejemplares similares

Ejemplares similares