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A Newly Synthesized Flavone from Luteolin Escapes from COMT-Catalyzed Methylation and Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages via JNK, p38 and NF-κB Signaling Pathways

Luteolin is a common dietary flavone possessing potent anti-inflammatory activities. However, when administrated in vivo, luteolin becomes methylated by catechol-O-methyltransferases (COMT) owing to the catechol ring in the chemical structure, which largely diminishes its anti-inflammatory effect. I...

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Detalles Bibliográficos
Autores principales:	Ye, Lin, Xin, Yang, Wu, Zhi-yuan, Sun, Hai-jian, Huang, De-jian, Sun, Zhi-qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society for Microbiology and Biotechnology 2022
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628824/ https://www.ncbi.nlm.nih.gov/pubmed/34099595 http://dx.doi.org/10.4014/jmb.2104.04027

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