Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)

An improved method for the synthesis of enantiomerically pure d-cyclopentenyl nucleosides has been accomplished and their antiviral activity against orthopox viruses have been evaluated. The key intermediate, l-cyclopent-2-enone 13 was prepared from d-ribose using a ring closing metathesis reaction...

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Detalles Bibliográficos
Autores principales: Chu, C.K, Jin, Y.H, Baker, R.O, Huggins, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628949/
https://www.ncbi.nlm.nih.gov/pubmed/12467606
http://dx.doi.org/10.1016/S0960-894X(02)00841-7
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author Chu, C.K
Jin, Y.H
Baker, R.O
Huggins, J
author_facet Chu, C.K
Jin, Y.H
Baker, R.O
Huggins, J
author_sort Chu, C.K
collection PubMed
description An improved method for the synthesis of enantiomerically pure d-cyclopentenyl nucleosides has been accomplished and their antiviral activity against orthopox viruses have been evaluated. The key intermediate, l-cyclopent-2-enone 13 was prepared from d-ribose using a ring closing metathesis reaction in eight steps. Among the synthesized nucleosides, the adenine 2 (Neplanocin A), cytosine 14, and 5-F-cytosine 15 analogues exhibited potent anti-orthopox virus activity, including smallpox virus.
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spelling pubmed-96289492022-11-03 Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox) Chu, C.K Jin, Y.H Baker, R.O Huggins, J Bioorg Med Chem Lett Article An improved method for the synthesis of enantiomerically pure d-cyclopentenyl nucleosides has been accomplished and their antiviral activity against orthopox viruses have been evaluated. The key intermediate, l-cyclopent-2-enone 13 was prepared from d-ribose using a ring closing metathesis reaction in eight steps. Among the synthesized nucleosides, the adenine 2 (Neplanocin A), cytosine 14, and 5-F-cytosine 15 analogues exhibited potent anti-orthopox virus activity, including smallpox virus. Elsevier Science Ltd. 2003-01 2002-12-03 /pmc/articles/PMC9628949/ /pubmed/12467606 http://dx.doi.org/10.1016/S0960-894X(02)00841-7 Text en Copyright © 2002 Elsevier Science Ltd. All rights reserved. Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.
spellingShingle Article
Chu, C.K
Jin, Y.H
Baker, R.O
Huggins, J
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)
title Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)
title_full Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)
title_fullStr Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)
title_full_unstemmed Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)
title_short Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)
title_sort antiviral activity of cyclopentenyl nucleosides against orthopox viruses (smallpox, monkeypox and cowpox)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628949/
https://www.ncbi.nlm.nih.gov/pubmed/12467606
http://dx.doi.org/10.1016/S0960-894X(02)00841-7
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