Dual role of benzophenone enables a fast and scalable C-4 selective alkylation of pyridines in flow

The efficient C-4 selective modification of pyridines is a major challenge for the synthetic community. Current strategies are plagued with at least one drawback regarding functional group-tolerant electronic activation of the heteroarene, mild generation of the required alkyl radicals, regioselecti...

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Detalles Bibliográficos
Autores principales: Sanjosé-Orduna, Jesús, Silva, Rodrigo C., Raymenants, Fabian, Reus, Bente, Thaens, Jannik, de Oliveira, Kleber T., Noël, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629060/
https://www.ncbi.nlm.nih.gov/pubmed/36382292
http://dx.doi.org/10.1039/d2sc04990b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629060/
https://www.ncbi.nlm.nih.gov/pubmed/36382292
http://dx.doi.org/10.1039/d2sc04990b

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