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Dual role of benzophenone enables a fast and scalable C-4 selective alkylation of pyridines in flow
The efficient C-4 selective modification of pyridines is a major challenge for the synthetic community. Current strategies are plagued with at least one drawback regarding functional group-tolerant electronic activation of the heteroarene, mild generation of the required alkyl radicals, regioselecti...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629060/ https://www.ncbi.nlm.nih.gov/pubmed/36382292 http://dx.doi.org/10.1039/d2sc04990b |