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Light-driven biocatalytic oxidation

Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired approaches for sustainable chemical synthesis. Oxidative enzymes (e.g., monooxygenases, peroxygenases, oxidases, or dehydrogenases) catalyze a variety of enantioselective oxyfunctionalization and dehydrogenat...

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Detalles Bibliográficos
Autores principales: Yun, Chul-Ho, Kim, Jinhyun, Hollmann, Frank, Park, Chan Beum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629115/
https://www.ncbi.nlm.nih.gov/pubmed/36382294
http://dx.doi.org/10.1039/d2sc03483b
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author Yun, Chul-Ho
Kim, Jinhyun
Hollmann, Frank
Park, Chan Beum
author_facet Yun, Chul-Ho
Kim, Jinhyun
Hollmann, Frank
Park, Chan Beum
author_sort Yun, Chul-Ho
collection PubMed
description Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired approaches for sustainable chemical synthesis. Oxidative enzymes (e.g., monooxygenases, peroxygenases, oxidases, or dehydrogenases) catalyze a variety of enantioselective oxyfunctionalization and dehydrogenation reactions under mild conditions. To sustain the catalytic cycles of these enzymes, constant supply with or withdrawal of reducing equivalents (electrons) is required. Being redox by nature, photocatalysis appears a ‘natural choice’ to accomplish the electron-relay role, and many photoenzymatic oxidation reactions have been developed in the past years. In this contribution, we critically summarize the current developments in photoredoxbiocatalysis, highlight some promising concepts but also discuss the current limitations.
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spelling pubmed-96291152022-11-14 Light-driven biocatalytic oxidation Yun, Chul-Ho Kim, Jinhyun Hollmann, Frank Park, Chan Beum Chem Sci Chemistry Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired approaches for sustainable chemical synthesis. Oxidative enzymes (e.g., monooxygenases, peroxygenases, oxidases, or dehydrogenases) catalyze a variety of enantioselective oxyfunctionalization and dehydrogenation reactions under mild conditions. To sustain the catalytic cycles of these enzymes, constant supply with or withdrawal of reducing equivalents (electrons) is required. Being redox by nature, photocatalysis appears a ‘natural choice’ to accomplish the electron-relay role, and many photoenzymatic oxidation reactions have been developed in the past years. In this contribution, we critically summarize the current developments in photoredoxbiocatalysis, highlight some promising concepts but also discuss the current limitations. The Royal Society of Chemistry 2022-09-30 /pmc/articles/PMC9629115/ /pubmed/36382294 http://dx.doi.org/10.1039/d2sc03483b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yun, Chul-Ho
Kim, Jinhyun
Hollmann, Frank
Park, Chan Beum
Light-driven biocatalytic oxidation
title Light-driven biocatalytic oxidation
title_full Light-driven biocatalytic oxidation
title_fullStr Light-driven biocatalytic oxidation
title_full_unstemmed Light-driven biocatalytic oxidation
title_short Light-driven biocatalytic oxidation
title_sort light-driven biocatalytic oxidation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629115/
https://www.ncbi.nlm.nih.gov/pubmed/36382294
http://dx.doi.org/10.1039/d2sc03483b
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