Cargando…

LBODP055 Discrimination Effectiveness Of Radiofrequency Echographic Multispectrometry As Non Invasive Method For Osteoporosis Diagnosis Applied To Elderly Women With Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fracture, although bone mineral density (BMD) is unaltered or higher in diabetic patients, measured by Dual-energy X-ray absorptiometry (DXA). This paradox could be explained from compromise bone microarchitecture that induce ab...

Descripción completa

Detalles Bibliográficos
Autores principales: Caffarelli, Carla, Pitinca, Maria Dea Tomai, Refaie, Antonella A, Giglio, Elisa, Lombardi, Fiorella Anna, Gonnelli, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629359/
http://dx.doi.org/10.1210/jendso/bvac150.565
_version_ 1784823382178529280
author Caffarelli, Carla
Pitinca, Maria Dea Tomai
Refaie, Antonella A
Giglio, Elisa
Lombardi, Fiorella Anna
Gonnelli, Stefano
author_facet Caffarelli, Carla
Pitinca, Maria Dea Tomai
Refaie, Antonella A
Giglio, Elisa
Lombardi, Fiorella Anna
Gonnelli, Stefano
author_sort Caffarelli, Carla
collection PubMed
description Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fracture, although bone mineral density (BMD) is unaltered or higher in diabetic patients, measured by Dual-energy X-ray absorptiometry (DXA). This paradox could be explained from compromise bone microarchitecture that induce abnormal bone cell function and matrix structure, with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption.1 In this context, a non-invasive method for assessing the bone density and quality on the axial reference sites (lumbar spine and proximal femur) called Radiofrequency Echographic Multi Spectrometry (REMS), has been introduced and clinically validated. This study aimed to evaluate whether the use of the REMS technique may improve the identification of osteoporosis in T2DM patients. A cohort of ABOUT 100 elderly women with T2DM and mean age 70.5 (± 7.6) years, and 100 healthy age-matched controls underwent DXA and REMS scans on the same anatomical sites (lumbar spine and proximal femur). DXA measurements were all higher in T2DM than controls; instead, all REMS​​ measurements were lower in T2DM than controls. Moreover, the percentage of T2DM women classified as "osteoporotic", on the basis of BMDREMS was markedly higher with respect to those classified by BMDDXA (47. 0% vs 28. 0%, respectively). On the contrary, the percentage of T2DM women classified as osteopenic or normal by BMDDXA was higher with respect by BMDREMS (48.8% and 23.2% vs 38.6% and 14.5%, respectively). T2DM women with fragility fractures presented lower values of both BMDDXA and BMDREMS at the lumbar spine with respect to those without fractures; however, the difference was significant only for BMDREMS (p<0. 05). In conclusion, BMDDXA, as expected, were higher in women with T2DM, while BMDREMS were lower in women with T2DM with respect to controls. Therefore, the data suggest that REMS could be a good diagnostic tool in demonstrating the diabetes-associated bone disease, due to its ability to assess bone quality2 and that may represent a useful approach to enhance the diagnosis of osteoporosis in patients with T2DM.1. Sanches, C. P., et al. The impact of type 2 diabetes on bone metabolism. Diabetol. Metab. Syndr. 9, 1-7 (2017).2. Adami, G. et al. Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study. Bone 134, 115297 (2020). Presentation: No date and time listed
format Online
Article
Text
id pubmed-9629359
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-96293592022-11-04 LBODP055 Discrimination Effectiveness Of Radiofrequency Echographic Multispectrometry As Non Invasive Method For Osteoporosis Diagnosis Applied To Elderly Women With Type 2 Diabetes Caffarelli, Carla Pitinca, Maria Dea Tomai Refaie, Antonella A Giglio, Elisa Lombardi, Fiorella Anna Gonnelli, Stefano J Endocr Soc Diabetes & Glucose Metabolism Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fracture, although bone mineral density (BMD) is unaltered or higher in diabetic patients, measured by Dual-energy X-ray absorptiometry (DXA). This paradox could be explained from compromise bone microarchitecture that induce abnormal bone cell function and matrix structure, with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption.1 In this context, a non-invasive method for assessing the bone density and quality on the axial reference sites (lumbar spine and proximal femur) called Radiofrequency Echographic Multi Spectrometry (REMS), has been introduced and clinically validated. This study aimed to evaluate whether the use of the REMS technique may improve the identification of osteoporosis in T2DM patients. A cohort of ABOUT 100 elderly women with T2DM and mean age 70.5 (± 7.6) years, and 100 healthy age-matched controls underwent DXA and REMS scans on the same anatomical sites (lumbar spine and proximal femur). DXA measurements were all higher in T2DM than controls; instead, all REMS​​ measurements were lower in T2DM than controls. Moreover, the percentage of T2DM women classified as "osteoporotic", on the basis of BMDREMS was markedly higher with respect to those classified by BMDDXA (47. 0% vs 28. 0%, respectively). On the contrary, the percentage of T2DM women classified as osteopenic or normal by BMDDXA was higher with respect by BMDREMS (48.8% and 23.2% vs 38.6% and 14.5%, respectively). T2DM women with fragility fractures presented lower values of both BMDDXA and BMDREMS at the lumbar spine with respect to those without fractures; however, the difference was significant only for BMDREMS (p<0. 05). In conclusion, BMDDXA, as expected, were higher in women with T2DM, while BMDREMS were lower in women with T2DM with respect to controls. Therefore, the data suggest that REMS could be a good diagnostic tool in demonstrating the diabetes-associated bone disease, due to its ability to assess bone quality2 and that may represent a useful approach to enhance the diagnosis of osteoporosis in patients with T2DM.1. Sanches, C. P., et al. The impact of type 2 diabetes on bone metabolism. Diabetol. Metab. Syndr. 9, 1-7 (2017).2. Adami, G. et al. Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study. Bone 134, 115297 (2020). Presentation: No date and time listed Oxford University Press 2022-11-01 /pmc/articles/PMC9629359/ http://dx.doi.org/10.1210/jendso/bvac150.565 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Diabetes & Glucose Metabolism
Caffarelli, Carla
Pitinca, Maria Dea Tomai
Refaie, Antonella A
Giglio, Elisa
Lombardi, Fiorella Anna
Gonnelli, Stefano
LBODP055 Discrimination Effectiveness Of Radiofrequency Echographic Multispectrometry As Non Invasive Method For Osteoporosis Diagnosis Applied To Elderly Women With Type 2 Diabetes
title LBODP055 Discrimination Effectiveness Of Radiofrequency Echographic Multispectrometry As Non Invasive Method For Osteoporosis Diagnosis Applied To Elderly Women With Type 2 Diabetes
title_full LBODP055 Discrimination Effectiveness Of Radiofrequency Echographic Multispectrometry As Non Invasive Method For Osteoporosis Diagnosis Applied To Elderly Women With Type 2 Diabetes
title_fullStr LBODP055 Discrimination Effectiveness Of Radiofrequency Echographic Multispectrometry As Non Invasive Method For Osteoporosis Diagnosis Applied To Elderly Women With Type 2 Diabetes
title_full_unstemmed LBODP055 Discrimination Effectiveness Of Radiofrequency Echographic Multispectrometry As Non Invasive Method For Osteoporosis Diagnosis Applied To Elderly Women With Type 2 Diabetes
title_short LBODP055 Discrimination Effectiveness Of Radiofrequency Echographic Multispectrometry As Non Invasive Method For Osteoporosis Diagnosis Applied To Elderly Women With Type 2 Diabetes
title_sort lbodp055 discrimination effectiveness of radiofrequency echographic multispectrometry as non invasive method for osteoporosis diagnosis applied to elderly women with type 2 diabetes
topic Diabetes & Glucose Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629359/
http://dx.doi.org/10.1210/jendso/bvac150.565
work_keys_str_mv AT caffarellicarla lbodp055discriminationeffectivenessofradiofrequencyechographicmultispectrometryasnoninvasivemethodforosteoporosisdiagnosisappliedtoelderlywomenwithtype2diabetes
AT pitincamariadeatomai lbodp055discriminationeffectivenessofradiofrequencyechographicmultispectrometryasnoninvasivemethodforosteoporosisdiagnosisappliedtoelderlywomenwithtype2diabetes
AT refaieantonellaa lbodp055discriminationeffectivenessofradiofrequencyechographicmultispectrometryasnoninvasivemethodforosteoporosisdiagnosisappliedtoelderlywomenwithtype2diabetes
AT giglioelisa lbodp055discriminationeffectivenessofradiofrequencyechographicmultispectrometryasnoninvasivemethodforosteoporosisdiagnosisappliedtoelderlywomenwithtype2diabetes
AT lombardifiorellaanna lbodp055discriminationeffectivenessofradiofrequencyechographicmultispectrometryasnoninvasivemethodforosteoporosisdiagnosisappliedtoelderlywomenwithtype2diabetes
AT gonnellistefano lbodp055discriminationeffectivenessofradiofrequencyechographicmultispectrometryasnoninvasivemethodforosteoporosisdiagnosisappliedtoelderlywomenwithtype2diabetes