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Homologous gene regulatory networks control development of apical organs and brains in Bilateria
Apical organs are relatively simple larval nervous systems. The extent to which apical organs are evolutionarily related to the more complex nervous systems of other animals remains unclear. To identify common developmental mechanisms, we analyzed the gene regulatory network (GRN) controlling the de...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629743/ https://www.ncbi.nlm.nih.gov/pubmed/36322649 http://dx.doi.org/10.1126/sciadv.abo2416 |
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author | Feuda, Roberto Peter, Isabelle S. |
author_facet | Feuda, Roberto Peter, Isabelle S. |
author_sort | Feuda, Roberto |
collection | PubMed |
description | Apical organs are relatively simple larval nervous systems. The extent to which apical organs are evolutionarily related to the more complex nervous systems of other animals remains unclear. To identify common developmental mechanisms, we analyzed the gene regulatory network (GRN) controlling the development of the apical organ in sea urchins. We characterized the developmental expression of 30 transcription factors and identified key regulatory functions for FoxQ2, Hbn, Delta/Notch signaling, and SoxC in the patterning of the apical organ and the specification of neurons. Almost the entire set of apical transcription factors is expressed in the nervous system of worms, flies, zebrafish, frogs, and mice. Furthermore, a regulatory module controlling the axial patterning of the vertebrate brain is expressed in the ectoderm of sea urchin embryos. We conclude that GRNs controlling the formation of bilaterian nervous systems share a common origin and that the apical GRN likely resembles an ancestral regulatory program. |
format | Online Article Text |
id | pubmed-9629743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96297432022-11-04 Homologous gene regulatory networks control development of apical organs and brains in Bilateria Feuda, Roberto Peter, Isabelle S. Sci Adv Biomedicine and Life Sciences Apical organs are relatively simple larval nervous systems. The extent to which apical organs are evolutionarily related to the more complex nervous systems of other animals remains unclear. To identify common developmental mechanisms, we analyzed the gene regulatory network (GRN) controlling the development of the apical organ in sea urchins. We characterized the developmental expression of 30 transcription factors and identified key regulatory functions for FoxQ2, Hbn, Delta/Notch signaling, and SoxC in the patterning of the apical organ and the specification of neurons. Almost the entire set of apical transcription factors is expressed in the nervous system of worms, flies, zebrafish, frogs, and mice. Furthermore, a regulatory module controlling the axial patterning of the vertebrate brain is expressed in the ectoderm of sea urchin embryos. We conclude that GRNs controlling the formation of bilaterian nervous systems share a common origin and that the apical GRN likely resembles an ancestral regulatory program. American Association for the Advancement of Science 2022-11-02 /pmc/articles/PMC9629743/ /pubmed/36322649 http://dx.doi.org/10.1126/sciadv.abo2416 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Feuda, Roberto Peter, Isabelle S. Homologous gene regulatory networks control development of apical organs and brains in Bilateria |
title | Homologous gene regulatory networks control development of apical organs and brains in Bilateria |
title_full | Homologous gene regulatory networks control development of apical organs and brains in Bilateria |
title_fullStr | Homologous gene regulatory networks control development of apical organs and brains in Bilateria |
title_full_unstemmed | Homologous gene regulatory networks control development of apical organs and brains in Bilateria |
title_short | Homologous gene regulatory networks control development of apical organs and brains in Bilateria |
title_sort | homologous gene regulatory networks control development of apical organs and brains in bilateria |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629743/ https://www.ncbi.nlm.nih.gov/pubmed/36322649 http://dx.doi.org/10.1126/sciadv.abo2416 |
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