Reactive oxygen species contribute to delirium-like behavior by activating CypA/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery

Postoperative delirium (POD) is common in the elderly and is associated with poor clinical outcomes. Reactive oxygen species (ROS) and blood-brain barrier (BBB) damage have been implicated in the development of POD, but the association between these two factors and the potential mechanism is not cle...

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Detalles Bibliográficos
Autores principales: Liu, Li-fang, Hu, Yun, Liu, Yi-nuo, Shi, De-wen, Liu, Chang, Da, Xin, Zhu, Si-hui, Zhu, Qian-yun, Zhang, Ji-qian, Xu, Guang-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629746/
https://www.ncbi.nlm.nih.gov/pubmed/36337710
http://dx.doi.org/10.3389/fnagi.2022.1021129

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