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An update on the role of complement in hepatocellular carcinoma
As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight association between improper complement activation in tu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629811/ https://www.ncbi.nlm.nih.gov/pubmed/36341431 http://dx.doi.org/10.3389/fimmu.2022.1007382 |
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author | Xiao, Zhijie Yeung, Charlie Lot Sum Yam, Judy Wai Ping Mao, Xiaowen |
author_facet | Xiao, Zhijie Yeung, Charlie Lot Sum Yam, Judy Wai Ping Mao, Xiaowen |
author_sort | Xiao, Zhijie |
collection | PubMed |
description | As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight association between improper complement activation in tumour initiation and progression. As complement activation predominantly occurs within the liver, the protumourigenic role of the complement system may contribute to the development of hepatocellular carcinoma (HCC). Improvement in the understanding of the molecular targets involved in complement-mediated tumour development, metastasis, and tumour-promoting inflammation in HCC would certainly aid in the development of better treatments. This minireview is focused on recent findings of the protumourigenic role of the complement system in HCC. |
format | Online Article Text |
id | pubmed-9629811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96298112022-11-03 An update on the role of complement in hepatocellular carcinoma Xiao, Zhijie Yeung, Charlie Lot Sum Yam, Judy Wai Ping Mao, Xiaowen Front Immunol Immunology As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight association between improper complement activation in tumour initiation and progression. As complement activation predominantly occurs within the liver, the protumourigenic role of the complement system may contribute to the development of hepatocellular carcinoma (HCC). Improvement in the understanding of the molecular targets involved in complement-mediated tumour development, metastasis, and tumour-promoting inflammation in HCC would certainly aid in the development of better treatments. This minireview is focused on recent findings of the protumourigenic role of the complement system in HCC. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9629811/ /pubmed/36341431 http://dx.doi.org/10.3389/fimmu.2022.1007382 Text en Copyright © 2022 Xiao, Yeung, Yam and Mao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Xiao, Zhijie Yeung, Charlie Lot Sum Yam, Judy Wai Ping Mao, Xiaowen An update on the role of complement in hepatocellular carcinoma |
title | An update on the role of complement in hepatocellular carcinoma |
title_full | An update on the role of complement in hepatocellular carcinoma |
title_fullStr | An update on the role of complement in hepatocellular carcinoma |
title_full_unstemmed | An update on the role of complement in hepatocellular carcinoma |
title_short | An update on the role of complement in hepatocellular carcinoma |
title_sort | update on the role of complement in hepatocellular carcinoma |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629811/ https://www.ncbi.nlm.nih.gov/pubmed/36341431 http://dx.doi.org/10.3389/fimmu.2022.1007382 |
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