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An update on the role of complement in hepatocellular carcinoma

As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight association between improper complement activation in tu...

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Autores principales: Xiao, Zhijie, Yeung, Charlie Lot Sum, Yam, Judy Wai Ping, Mao, Xiaowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629811/
https://www.ncbi.nlm.nih.gov/pubmed/36341431
http://dx.doi.org/10.3389/fimmu.2022.1007382
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author Xiao, Zhijie
Yeung, Charlie Lot Sum
Yam, Judy Wai Ping
Mao, Xiaowen
author_facet Xiao, Zhijie
Yeung, Charlie Lot Sum
Yam, Judy Wai Ping
Mao, Xiaowen
author_sort Xiao, Zhijie
collection PubMed
description As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight association between improper complement activation in tumour initiation and progression. As complement activation predominantly occurs within the liver, the protumourigenic role of the complement system may contribute to the development of hepatocellular carcinoma (HCC). Improvement in the understanding of the molecular targets involved in complement-mediated tumour development, metastasis, and tumour-promoting inflammation in HCC would certainly aid in the development of better treatments. This minireview is focused on recent findings of the protumourigenic role of the complement system in HCC.
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spelling pubmed-96298112022-11-03 An update on the role of complement in hepatocellular carcinoma Xiao, Zhijie Yeung, Charlie Lot Sum Yam, Judy Wai Ping Mao, Xiaowen Front Immunol Immunology As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight association between improper complement activation in tumour initiation and progression. As complement activation predominantly occurs within the liver, the protumourigenic role of the complement system may contribute to the development of hepatocellular carcinoma (HCC). Improvement in the understanding of the molecular targets involved in complement-mediated tumour development, metastasis, and tumour-promoting inflammation in HCC would certainly aid in the development of better treatments. This minireview is focused on recent findings of the protumourigenic role of the complement system in HCC. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9629811/ /pubmed/36341431 http://dx.doi.org/10.3389/fimmu.2022.1007382 Text en Copyright © 2022 Xiao, Yeung, Yam and Mao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xiao, Zhijie
Yeung, Charlie Lot Sum
Yam, Judy Wai Ping
Mao, Xiaowen
An update on the role of complement in hepatocellular carcinoma
title An update on the role of complement in hepatocellular carcinoma
title_full An update on the role of complement in hepatocellular carcinoma
title_fullStr An update on the role of complement in hepatocellular carcinoma
title_full_unstemmed An update on the role of complement in hepatocellular carcinoma
title_short An update on the role of complement in hepatocellular carcinoma
title_sort update on the role of complement in hepatocellular carcinoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629811/
https://www.ncbi.nlm.nih.gov/pubmed/36341431
http://dx.doi.org/10.3389/fimmu.2022.1007382
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