Cargando…

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway

Acute myeloid leukemia (AML) is the most lethal form of AML due to disease relapse. Cyclin dependent kinase 8 (CDK8) is a serine/threonine kinase that belongs to the family of Cyclin-dependent kinases and is an emerging target for the treatment of AML. MK256, a potent, selective, and orally availabl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jen-Chieh, Liu, Shu, Wang, Yucheng, Liang, You, Jablons, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629815/ https://www.ncbi.nlm.nih.gov/pubmed/36342456 http://dx.doi.org/10.18632/oncotarget.28305

Ejemplares similares

In Vivo Antitumor Effects of MK615 Led by PD-L1 Downregulation
por: Yanaki, Masashi, et al.
Publicado: (2018)

SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains
por: Rzymski, Tomasz, et al.
Publicado: (2017)

Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer
por: Lin, Wen-Hsing, et al.
Publicado: (2014)

CDK8 as the STAT1 serine 727 kinase?
por: Staab, Julia, et al.
Publicado: (2013)

A Computational Study on Thiourea Analogs as Potent MK-2 Inhibitors
por: Hao, Ming, et al.
Publicado: (2012)

MK‐6, a novel not‐α IL‐2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance
por: Kobayashi, Maki, et al.
Publicado: (2021)

Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3
por: Wu, Song, et al.
Publicado: (2018)

Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis
por: Aftabizadeh, Maryam, et al.
Publicado: (2021)

Imaging by photon counting with 256 x 256 pixel matrix
por: Tlustos, Lukas, et al.
Publicado: (2004)

CDK6 Inhibition: A Novel Approach in AML Management
por: Uras, Iris Z., et al.
Publicado: (2020)

Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition
por: Xu, Shaohua, et al.
Publicado: (2021)

Stat3 Inhibitor Stattic Exhibits Potent Antitumor Activity and Induces Chemo- and Radio-Sensitivity in Nasopharyngeal Carcinoma
por: Pan, Yunbao, et al.
Publicado: (2013)

Momelotinib is a highly potent inhibitor of FLT3-mutant AML
por: Azhar, Mohammad, et al.
Publicado: (2022)

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
por: Mallinger, Aurélie, et al.
Publicado: (2016)

Downregulation of stromal syntenin sustains AML development
por: Leblanc, Raphael, et al.
Publicado: (2023)

MicroRNA let-7b downregulates AML1-ETO oncogene expression in t(8;21) AML by targeting its 3′UTR
por: Johnson, Daniel T., et al.
Publicado: (2021)

Dual targeting of CDK4/6 and Bcl-2 exhibits a potent antitumor effect on mantle cell lymphoma
por: Che, Yuxuan, et al.
Publicado: (2023)

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
por: Whittaker, Steven R., et al.
Publicado: (2018)

Correction: Stat3 inhibitor stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma
por: Pan, Yunbao, et al.
Publicado: (2020)

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
por: Layton, Mark E., et al.
Publicado: (2023)

First Human Results With the 256 Channel Intelligent Micro Implant Eye (IMIE 256)
por: Xu, Huizhuo, et al.
Publicado: (2021)

Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells
por: Miao, Xue-Rong, et al.
Publicado: (2010)

Iterative Conversion of Cyclin Binding Groove Peptides into Druglike CDK Inhibitors with Antitumor Activity
por: Premnath, Padmavathy Nandha, et al.
Publicado: (2014)

Health Tract, No. 256: Accidents
Publicado: (1866)

CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response
por: Bancerek, Joanna, et al.
Publicado: (2013)

Abscopal antitumor immune effects of magnet-mediated hyperthermia at a high therapeutic temperature on Walker-256 carcinosarcomas in rats
por: WANG, HUI, et al.
Publicado: (2014)

LPM3770277, a Potent Novel CDK4/6 Degrader, Exerts Antitumor Effect Against Triple-Negative Breast Cancer
por: Qiu, Jiahao, et al.
Publicado: (2022)

Bromodomain inhibitor OTX015 (MK-8628) combined with targeted agents shows strong in vivo antitumor activity in lymphoma
por: Gaudio, Eugenio, et al.
Publicado: (2016)

Engineering and characterising a novel, highly potent bispecific antibody iMab-CAP256 that targets HIV-1
por: Moshoette, Tumelo, et al.
Publicado: (2019)

Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML
por: Chantkran, Wittawat, et al.
Publicado: (2021)

HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML
por: Li, Zheng, et al.
Publicado: (2021)

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13
por: Yang, Jianzhang, et al.
Publicado: (2022)

Downregulation of CD73 associates with T cell exhaustion in AML patients
por: Kong, Yaxian, et al.
Publicado: (2019)

256 Addressing the Underdiagnosis of Familial Hypercholesterolemia
por: Kalia, Isha, et al.
Publicado: (2023)

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19
por: Mallinger, Aurélie, et al.
Publicado: (2016)

A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase
por: Sakurikar, Nandini, et al.
Publicado: (2015)

Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2
por: Gurgis, FMS, et al.
Publicado: (2015)

Biological Effects of BET Inhibition by OTX015 (MK-8628) and JQ1 in NPM1-Mutated (NPM1c) Acute Myeloid Leukemia (AML)
por: Djamai, Hanane, et al.
Publicado: (2021)

CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance
por: Putz, Eva Maria, et al.
Publicado: (2013)

Combretastatin-A4 phosphate improves the distribution and antitumor efficacy of albumin-bound paclitaxel in W256 breast carcinoma model
por: Gao, Meng, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_86ih21itdq1ej1ncmvkt2iaes5