Cargando…

Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex

Transient dark exposure, typically 7–10 days in duration, followed by light reintroduction is an emerging treatment for improving the restoration of vision in amblyopic subjects whose occlusion is removed in adulthood. Dark exposure initiates homeostatic mechanisms that together with light-induced c...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeon, Brian B, Fuchs, Thomas, Chase, Steven M, Kuhlman, Sandra J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629826/
https://www.ncbi.nlm.nih.gov/pubmed/36321876
http://dx.doi.org/10.7554/eLife.80361
_version_ 1784823474161713152
author Jeon, Brian B
Fuchs, Thomas
Chase, Steven M
Kuhlman, Sandra J
author_facet Jeon, Brian B
Fuchs, Thomas
Chase, Steven M
Kuhlman, Sandra J
author_sort Jeon, Brian B
collection PubMed
description Transient dark exposure, typically 7–10 days in duration, followed by light reintroduction is an emerging treatment for improving the restoration of vision in amblyopic subjects whose occlusion is removed in adulthood. Dark exposure initiates homeostatic mechanisms that together with light-induced changes in cellular signaling pathways result in the re-engagement of juvenile-like plasticity in the adult such that previously deprived inputs can gain cortical territory. It is possible that dark exposure itself degrades visual responses, and this could place constraints on the optimal duration of dark exposure treatment. To determine whether eight days of dark exposure has a lasting negative impact on responses to classic grating stimuli, neural activity was recorded before and after dark exposure in awake head-fixed mice using two-photon calcium imaging. Neural discriminability, assessed using classifiers, was transiently reduced following dark exposure; a decrease in response reliability across a broad range of spatial frequencies likely contributed to the disruption. Both discriminability and reliability recovered. Fixed classifiers were used to demonstrate that stimulus representation rebounded to the original, pre-deprivation state, thus dark exposure did not appear to have a lasting negative impact on visual processing. Unexpectedly, we found that dark exposure significantly stabilized orientation preference and signal correlation. Our results reveal that natural vision exerts a disrupting influence on the stability of stimulus preference for classic grating stimuli and, at the same time, improves neural discriminability for both low and high-spatial frequency stimuli.
format Online
Article
Text
id pubmed-9629826
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-96298262022-11-03 Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex Jeon, Brian B Fuchs, Thomas Chase, Steven M Kuhlman, Sandra J eLife Neuroscience Transient dark exposure, typically 7–10 days in duration, followed by light reintroduction is an emerging treatment for improving the restoration of vision in amblyopic subjects whose occlusion is removed in adulthood. Dark exposure initiates homeostatic mechanisms that together with light-induced changes in cellular signaling pathways result in the re-engagement of juvenile-like plasticity in the adult such that previously deprived inputs can gain cortical territory. It is possible that dark exposure itself degrades visual responses, and this could place constraints on the optimal duration of dark exposure treatment. To determine whether eight days of dark exposure has a lasting negative impact on responses to classic grating stimuli, neural activity was recorded before and after dark exposure in awake head-fixed mice using two-photon calcium imaging. Neural discriminability, assessed using classifiers, was transiently reduced following dark exposure; a decrease in response reliability across a broad range of spatial frequencies likely contributed to the disruption. Both discriminability and reliability recovered. Fixed classifiers were used to demonstrate that stimulus representation rebounded to the original, pre-deprivation state, thus dark exposure did not appear to have a lasting negative impact on visual processing. Unexpectedly, we found that dark exposure significantly stabilized orientation preference and signal correlation. Our results reveal that natural vision exerts a disrupting influence on the stability of stimulus preference for classic grating stimuli and, at the same time, improves neural discriminability for both low and high-spatial frequency stimuli. eLife Sciences Publications, Ltd 2022-11-02 /pmc/articles/PMC9629826/ /pubmed/36321876 http://dx.doi.org/10.7554/eLife.80361 Text en © 2022, Jeon et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Jeon, Brian B
Fuchs, Thomas
Chase, Steven M
Kuhlman, Sandra J
Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex
title Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex
title_full Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex
title_fullStr Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex
title_full_unstemmed Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex
title_short Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex
title_sort visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629826/
https://www.ncbi.nlm.nih.gov/pubmed/36321876
http://dx.doi.org/10.7554/eLife.80361
work_keys_str_mv AT jeonbrianb visualexperiencehasopposinginfluencesonthequalityofstimulusrepresentationinadultprimaryvisualcortex
AT fuchsthomas visualexperiencehasopposinginfluencesonthequalityofstimulusrepresentationinadultprimaryvisualcortex
AT chasestevenm visualexperiencehasopposinginfluencesonthequalityofstimulusrepresentationinadultprimaryvisualcortex
AT kuhlmansandraj visualexperiencehasopposinginfluencesonthequalityofstimulusrepresentationinadultprimaryvisualcortex