A reconstituted depolarization-induced Ca(2+) release platform for validation of skeletal muscle disease mutations and drug discovery

In skeletal muscle excitation–contraction (E–C) coupling, depolarization of the plasma membrane triggers Ca(2+) release from the sarcoplasmic reticulum (SR), referred to as depolarization-induced Ca(2+) release (DICR). DICR occurs through the type 1 ryanodine receptor (RyR1), which physically intera...

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Detalles Bibliográficos
Autores principales: Murayama, Takashi, Kurebayashi, Nagomi, Numaga-Tomita, Takuro, Kobayashi, Takuya, Okazaki, Satoru, Yamashiro, Kyosuke, Nakada, Tsutomu, Mori, Shuichi, Ishida, Ryosuke, Kagechika, Hiroyuki, Yamada, Mitsuhiko, Sakurai, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Methods and Approaches
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629852/
https://www.ncbi.nlm.nih.gov/pubmed/36318155
http://dx.doi.org/10.1085/jgp.202213230

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