Cargando…

Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L-arginine to urea and L-ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 (ARG2), play a vital role in the regulation of β-cell functions, insulin resistance (IR), and vascular complications via modulati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Yuanyuan, Li, Zhuozhuo, Li, Wenqing, Fan, Xiaobin, Han, Feifei, Huang, Yaoyao, Yu, Yi, Qian, Lu, Xiong, Yuyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629921/ https://www.ncbi.nlm.nih.gov/pubmed/36338341 http://dx.doi.org/10.1155/2022/2419412

Ejemplares similares

Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases
por: Li, Zhuozhuo, et al.
Publicado: (2022)

Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma: The role of Arginase 2 in sorafenib-induced ferroptosis in melanoma
por: Yu, Yi, et al.
Publicado: (2022)

Identification of A Novel Gene Signature Combining Ferroptosis- and Immunity-Related Genes for Prognostic Prediction, Immunotherapy and Potential Therapeutic Targets in Gastric Cancer
por: Wang, Liwei, et al.
Publicado: (2023)

Arginase-II Deficiency Extends Lifespan in Mice
por: Xiong, Yuyan, et al.
Publicado: (2017)

Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function
por: Niu, Fanglin, et al.
Publicado: (2023)

The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer
por: Avtandilyan, Nikolay, et al.
Publicado: (2018)

Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability
por: Xiong, Yuyan, et al.
Publicado: (2013)

Arginase 1 deficiency presenting as complicated hereditary spastic paraplegia
por: Freua, Fernando, et al.
Publicado: (2022)

Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis
por: Yu, Yi, et al.
Publicado: (2018)

Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity
por: Huang, Ji, et al.
Publicado: (2016)

Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation
por: Yang, Zhihong, et al.
Publicado: (2013)

Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?
por: Shosha, Esraa, et al.
Publicado: (2020)

Arginase and pulmonary diseases
por: Maarsingh, Harm, et al.
Publicado: (2008)

Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications
por: Yimer, Ebrahim M., et al.
Publicado: (2018)

Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance
por: Tommasi, S., et al.
Publicado: (2018)

Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma()
por: Bratt, Jennifer M., et al.
Publicado: (2011)

Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise
por: Carter, Nicola S., et al.
Publicado: (2021)

Cinnamide Derivatives as Mammalian Arginase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking
por: Pham, Thanh-Nhat, et al.
Publicado: (2016)

Evidence for tmTNF reverse signaling in vivo: Implications for an arginase-1-mediated therapeutic effect of TNF inhibitors during inflammation
por: Diallo, Katy, et al.
Publicado: (2021)

Arginase and Arginine Dysregulation in Asthma
por: Benson, Renée C., et al.
Publicado: (2011)

Endothelial arginase II and atherosclerosis
por: Ryoo, Sungwoo, et al.
Publicado: (2011)

Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients
por: WANG, SONG, et al.
Publicado: (2014)

Arginase Gene Polymorphism Increases Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
por: Buraczynska, Monika, et al.
Publicado: (2021)

Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues
por: Fouda, Abdelrahman Y., et al.
Publicado: (2020)

Androgen-Regulated Expression of Arginase 1, Arginase 2 and Interleukin-8 in Human Prostate Cancer
por: Gannon, Philippe O., et al.
Publicado: (2010)

Role of p38 mitogen-activated protein kinase in vascular endothelial aging: Interaction with Arginase-II and S6K1 signaling pathway
por: Wu, Zongsong, et al.
Publicado: (2015)

Arginase: Mechanisms and Clinical Application in Hematologic Malignancy
por: Du, Zefan, et al.
Publicado: (2022)

A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor
por: Shen, Weitao, et al.
Publicado: (2017)

Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging
por: Yu, Yi, et al.
Publicado: (2023)

KCl-Dependent Release of Mitochondrial Membrane-Bound Arginase Appears to Be a Novel Variant of Arginase-II
por: Suman, Mishra, et al.
Publicado: (2016)

Effect of Arginase Inhibition on Ischemia-Reperfusion Injury in Patients with Coronary Artery Disease with and without Diabetes Mellitus
por: Kövamees, Oskar, et al.
Publicado: (2014)

Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase
por: Mahdi, Ali, et al.
Publicado: (2020)

Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency
por: Ballantyne, Laurel L., et al.
Publicado: (2016)

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis
por: Ming, Xiu‐Fen, et al.
Publicado: (2012)

Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway
por: Zhang, Lili, et al.
Publicado: (2021)

Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
por: Zhang, Yiming, et al.
Publicado: (2019)

Characterization of Arginase Expression in Glioma-Associated Microglia and Macrophages
por: Zhang, Ian, et al.
Publicado: (2016)

The Effect of Arginase on the Retardation of Tumour Growth
por: Bach, S. J., et al.
Publicado: (1965)

Role of Arginase in Vessel Wall Remodeling
por: Durante, William
Publicado: (2013)

Arginase as a Mediator of Diabetic Retinopathy
por: Patel, Chintan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_l86s8mlk39sbplbd0tcpvcp7mt