Cargando…

Somatic Mutations of TP53 Identified by Targeted Next-Generation Sequencing Are Poor Prognostic Factors for Primary Operable Breast Cancer: A Single-Center Study

Few studies have reported on the clinical utility of targeted next-generation sequencing (NGS) for breast cancer in Korea. We retrospectively reviewed the targeted NGS data of 219 patients with breast cancer who underwent surgical resection between August 2018 and April 2021. Here, we described the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jung Ho, Kwon, Mi Jung, Seo, Jinwon, Kim, Ho Young, Min, Soo Kee, Kim, Lee Su
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Breast Cancer Society 2022
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629967/ https://www.ncbi.nlm.nih.gov/pubmed/36265889 http://dx.doi.org/10.4048/jbc.2022.25.e41

Ejemplares similares

Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation
por: Chui, M Herman, et al.
Publicado: (2021)

Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer
por: Choi, Jin Hyuk, et al.
Publicado: (2023)

Somatic Mutations of TP53 and Prognostic Factors for Primary Operable Breast Cancer: Correspondence
por: Sookaromdee, Pathum, et al.
Publicado: (2022)

TP53 Alterations Are Associated With Poor Survival in Patients With Primary Mediastinal Nonseminoma Germ Cell Tumors
por: Bacon, Jack V W, et al.
Publicado: (2022)

Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer
por: Hwang, Hye Jung, et al.
Publicado: (2020)

Immunohistochemical correlates of TP53 somatic mutations in cancer
por: Murnyák, Balázs, et al.
Publicado: (2016)

TP53 mutations predict poor response to immunotherapy in patients with metastatic solid tumors
por: Kim, Ji‐Yeon, et al.
Publicado: (2023)

Simultaneous Occurrence of Ductal Carcinoma In Situ within Juvenile Fibroadenoma in Both Breasts: A Brief Case Report
por: Kwon, Mi Jung, et al.
Publicado: (2014)

Identification of Novel Somatic TP53 Mutations in Patients with High-Grade Serous Ovarian Cancer (HGSOC) Using Next-Generation Sequencing (NGS)
por: Garziera, Marica, et al.
Publicado: (2018)

Low Rate of Detection of Mucosal High-Risk-Type Human Papillomavirus in Korean Patients with Extragenital Bowen's Disease and Squamous Cell Carcinoma, Especially in Digital Cases
por: Park, Hye-Rim, et al.
Publicado: (2013)

Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers
por: Zhang, Wensheng, et al.
Publicado: (2017)

Prognostic Value of the TP53 Mutation Location in Metastatic Breast Cancer as Detected by Next-Generation Sequencing
por: Bai, Han, et al.
Publicado: (2021)

Programmed death ligand-1 and MET co-expression is a poor prognostic factor in gastric cancers after resection
por: Kwon, Mi Jung, et al.
Publicado: (2017)

A substantial proportion of apparently heterozygous TP53 pathogenic variants detected with a next‐generation sequencing hereditary pan‐cancer panel are acquired somatically
por: Coffee, Bradford, et al.
Publicado: (2019)

Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers
por: Faden, Daniel L., et al.
Publicado: (2016)

Impact of TP53 mutations in Triple Negative Breast Cancer
por: Mitri, Zahi I., et al.
Publicado: (2022)

Somatic TP53 variants frequently confound germline testing results
por: Weitzel, Jeffrey N., et al.
Publicado: (2017)

Immunological Role of TP53 Somatic Mutation Classification in Human Cancers
por: Fang, Jianfei, et al.
Publicado: (2023)

Somatic TP53 mutations are preleukemic events in acute lymphoblastic leukemia
por: Chitadze, Guranda, et al.
Publicado: (2023)

Clinical Targeted Next-Generation sequencing Panels for Detection of Somatic Variants in Gliomas
por: Shin, Hyemi, et al.
Publicado: (2020)

A Highly Sensitive Next-Generation Sequencing-Based Genotyping Platform for EGFR Mutations in Plasma from Non-Small Cell Lung Cancer Patients
por: Shin, Jung-Young, et al.
Publicado: (2020)

Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer
por: Ignacio, Rosa Mistica C., et al.
Publicado: (2018)

TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects
por: Ragu, Mohana Eswari, et al.
Publicado: (2023)

Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer
por: Bae, Eun Young, et al.
Publicado: (2011)

Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non–Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing
por: Shajani-Yi, Zahra, et al.
Publicado: (2018)

TP53 somatic mutations are associated with poor survival in non-small cell lung cancer patients who undergo immunotherapy
por: Zhao, Liqin, et al.
Publicado: (2020)

A Pathogenic Mosaic TP53 Mutation in Two Germ Layers Detected by Next Generation Sequencing
por: Behjati, Sam, et al.
Publicado: (2014)

Clinical significance of TP53 variants as possible secondary findings in tumor-only next-generation sequencing
por: Yamamoto, Yoshihiro, et al.
Publicado: (2019)

Genotyping Influenza Virus by Next-Generation Deep Sequencing in Clinical Specimens
por: Seong, Moon-Woo, et al.
Publicado: (2016)

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
por: Cho, Sung-Yup, et al.
Publicado: (2017)

Independent prognostic value of somatic TP53 gene mutations in 1794 breast cancer patients
por: Olivier, M, et al.
Publicado: (2005)

Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus
por: Lim, Sun Min, et al.
Publicado: (2016)

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53
por: Szczepny, Anette, et al.
Publicado: (2018)

PIK3CA Mutation as Potential Poor Prognostic Marker in Asian Female Breast Cancer Patients Who Received Adjuvant Chemotherapy
por: Cho, Yoon Ah, et al.
Publicado: (2022)

Mesonephric Adenocarcinoma of the Vagina Harboring TP53 Mutation
por: Lee, Hyunjee, et al.
Publicado: (2022)

The spectrum of subclonal TP53 mutations in chronic lymphocytic leukemia: A next generation sequencing retrospective study
por: De Luca, Giuseppa, et al.
Publicado: (2022)

Frequent Premature Atrial Contractions as a Poor Prognostic Factor in Cryptogenic Stroke Patients with Concomitant Non-Sustained Atrial Tachycardia
por: Cha, Jung-Joon, et al.
Publicado: (2020)

The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
por: Kim, Junho, et al.
Publicado: (2019)

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer
por: Abdeen, Suhaib K., et al.
Publicado: (2018)

Comprehensive analyses of somatic TP53 mutation in tumors with variable mutant allele frequency
por: Cole, Alexander J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_25n4urhvvurfjps67t5q0uqms2