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Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission t...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630096/ https://www.ncbi.nlm.nih.gov/pubmed/36303070 http://dx.doi.org/10.1038/s41593-022-01186-3 |
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author | Hansen, Justine Y. Shafiei, Golia Markello, Ross D. Smart, Kelly Cox, Sylvia M. L. Nørgaard, Martin Beliveau, Vincent Wu, Yanjun Gallezot, Jean-Dominique Aumont, Étienne Servaes, Stijn Scala, Stephanie G. DuBois, Jonathan M. Wainstein, Gabriel Bezgin, Gleb Funck, Thomas Schmitz, Taylor W. Spreng, R. Nathan Galovic, Marian Koepp, Matthias J. Duncan, John S. Coles, Jonathan P. Fryer, Tim D. Aigbirhio, Franklin I. McGinnity, Colm J. Hammers, Alexander Soucy, Jean-Paul Baillet, Sylvain Guimond, Synthia Hietala, Jarmo Bedard, Marc-André Leyton, Marco Kobayashi, Eliane Rosa-Neto, Pedro Ganz, Melanie Knudsen, Gitte M. Palomero-Gallagher, Nicola Shine, James M. Carson, Richard E. Tuominen, Lauri Dagher, Alain Misic, Bratislav |
author_facet | Hansen, Justine Y. Shafiei, Golia Markello, Ross D. Smart, Kelly Cox, Sylvia M. L. Nørgaard, Martin Beliveau, Vincent Wu, Yanjun Gallezot, Jean-Dominique Aumont, Étienne Servaes, Stijn Scala, Stephanie G. DuBois, Jonathan M. Wainstein, Gabriel Bezgin, Gleb Funck, Thomas Schmitz, Taylor W. Spreng, R. Nathan Galovic, Marian Koepp, Matthias J. Duncan, John S. Coles, Jonathan P. Fryer, Tim D. Aigbirhio, Franklin I. McGinnity, Colm J. Hammers, Alexander Soucy, Jean-Paul Baillet, Sylvain Guimond, Synthia Hietala, Jarmo Bedard, Marc-André Leyton, Marco Kobayashi, Eliane Rosa-Neto, Pedro Ganz, Melanie Knudsen, Gitte M. Palomero-Gallagher, Nicola Shine, James M. Carson, Richard E. Tuominen, Lauri Dagher, Alain Misic, Bratislav |
author_sort | Hansen, Justine Y. |
collection | PubMed |
description | Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization. |
format | Online Article Text |
id | pubmed-9630096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-96300962022-11-04 Mapping neurotransmitter systems to the structural and functional organization of the human neocortex Hansen, Justine Y. Shafiei, Golia Markello, Ross D. Smart, Kelly Cox, Sylvia M. L. Nørgaard, Martin Beliveau, Vincent Wu, Yanjun Gallezot, Jean-Dominique Aumont, Étienne Servaes, Stijn Scala, Stephanie G. DuBois, Jonathan M. Wainstein, Gabriel Bezgin, Gleb Funck, Thomas Schmitz, Taylor W. Spreng, R. Nathan Galovic, Marian Koepp, Matthias J. Duncan, John S. Coles, Jonathan P. Fryer, Tim D. Aigbirhio, Franklin I. McGinnity, Colm J. Hammers, Alexander Soucy, Jean-Paul Baillet, Sylvain Guimond, Synthia Hietala, Jarmo Bedard, Marc-André Leyton, Marco Kobayashi, Eliane Rosa-Neto, Pedro Ganz, Melanie Knudsen, Gitte M. Palomero-Gallagher, Nicola Shine, James M. Carson, Richard E. Tuominen, Lauri Dagher, Alain Misic, Bratislav Nat Neurosci Resource Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization. Nature Publishing Group US 2022-10-27 2022 /pmc/articles/PMC9630096/ /pubmed/36303070 http://dx.doi.org/10.1038/s41593-022-01186-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Resource Hansen, Justine Y. Shafiei, Golia Markello, Ross D. Smart, Kelly Cox, Sylvia M. L. Nørgaard, Martin Beliveau, Vincent Wu, Yanjun Gallezot, Jean-Dominique Aumont, Étienne Servaes, Stijn Scala, Stephanie G. DuBois, Jonathan M. Wainstein, Gabriel Bezgin, Gleb Funck, Thomas Schmitz, Taylor W. Spreng, R. Nathan Galovic, Marian Koepp, Matthias J. Duncan, John S. Coles, Jonathan P. Fryer, Tim D. Aigbirhio, Franklin I. McGinnity, Colm J. Hammers, Alexander Soucy, Jean-Paul Baillet, Sylvain Guimond, Synthia Hietala, Jarmo Bedard, Marc-André Leyton, Marco Kobayashi, Eliane Rosa-Neto, Pedro Ganz, Melanie Knudsen, Gitte M. Palomero-Gallagher, Nicola Shine, James M. Carson, Richard E. Tuominen, Lauri Dagher, Alain Misic, Bratislav Mapping neurotransmitter systems to the structural and functional organization of the human neocortex |
title | Mapping neurotransmitter systems to the structural and functional organization of the human neocortex |
title_full | Mapping neurotransmitter systems to the structural and functional organization of the human neocortex |
title_fullStr | Mapping neurotransmitter systems to the structural and functional organization of the human neocortex |
title_full_unstemmed | Mapping neurotransmitter systems to the structural and functional organization of the human neocortex |
title_short | Mapping neurotransmitter systems to the structural and functional organization of the human neocortex |
title_sort | mapping neurotransmitter systems to the structural and functional organization of the human neocortex |
topic | Resource |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630096/ https://www.ncbi.nlm.nih.gov/pubmed/36303070 http://dx.doi.org/10.1038/s41593-022-01186-3 |
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