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Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission t...

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Autores principales: Hansen, Justine Y., Shafiei, Golia, Markello, Ross D., Smart, Kelly, Cox, Sylvia M. L., Nørgaard, Martin, Beliveau, Vincent, Wu, Yanjun, Gallezot, Jean-Dominique, Aumont, Étienne, Servaes, Stijn, Scala, Stephanie G., DuBois, Jonathan M., Wainstein, Gabriel, Bezgin, Gleb, Funck, Thomas, Schmitz, Taylor W., Spreng, R. Nathan, Galovic, Marian, Koepp, Matthias J., Duncan, John S., Coles, Jonathan P., Fryer, Tim D., Aigbirhio, Franklin I., McGinnity, Colm J., Hammers, Alexander, Soucy, Jean-Paul, Baillet, Sylvain, Guimond, Synthia, Hietala, Jarmo, Bedard, Marc-André, Leyton, Marco, Kobayashi, Eliane, Rosa-Neto, Pedro, Ganz, Melanie, Knudsen, Gitte M., Palomero-Gallagher, Nicola, Shine, James M., Carson, Richard E., Tuominen, Lauri, Dagher, Alain, Misic, Bratislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630096/
https://www.ncbi.nlm.nih.gov/pubmed/36303070
http://dx.doi.org/10.1038/s41593-022-01186-3
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author Hansen, Justine Y.
Shafiei, Golia
Markello, Ross D.
Smart, Kelly
Cox, Sylvia M. L.
Nørgaard, Martin
Beliveau, Vincent
Wu, Yanjun
Gallezot, Jean-Dominique
Aumont, Étienne
Servaes, Stijn
Scala, Stephanie G.
DuBois, Jonathan M.
Wainstein, Gabriel
Bezgin, Gleb
Funck, Thomas
Schmitz, Taylor W.
Spreng, R. Nathan
Galovic, Marian
Koepp, Matthias J.
Duncan, John S.
Coles, Jonathan P.
Fryer, Tim D.
Aigbirhio, Franklin I.
McGinnity, Colm J.
Hammers, Alexander
Soucy, Jean-Paul
Baillet, Sylvain
Guimond, Synthia
Hietala, Jarmo
Bedard, Marc-André
Leyton, Marco
Kobayashi, Eliane
Rosa-Neto, Pedro
Ganz, Melanie
Knudsen, Gitte M.
Palomero-Gallagher, Nicola
Shine, James M.
Carson, Richard E.
Tuominen, Lauri
Dagher, Alain
Misic, Bratislav
author_facet Hansen, Justine Y.
Shafiei, Golia
Markello, Ross D.
Smart, Kelly
Cox, Sylvia M. L.
Nørgaard, Martin
Beliveau, Vincent
Wu, Yanjun
Gallezot, Jean-Dominique
Aumont, Étienne
Servaes, Stijn
Scala, Stephanie G.
DuBois, Jonathan M.
Wainstein, Gabriel
Bezgin, Gleb
Funck, Thomas
Schmitz, Taylor W.
Spreng, R. Nathan
Galovic, Marian
Koepp, Matthias J.
Duncan, John S.
Coles, Jonathan P.
Fryer, Tim D.
Aigbirhio, Franklin I.
McGinnity, Colm J.
Hammers, Alexander
Soucy, Jean-Paul
Baillet, Sylvain
Guimond, Synthia
Hietala, Jarmo
Bedard, Marc-André
Leyton, Marco
Kobayashi, Eliane
Rosa-Neto, Pedro
Ganz, Melanie
Knudsen, Gitte M.
Palomero-Gallagher, Nicola
Shine, James M.
Carson, Richard E.
Tuominen, Lauri
Dagher, Alain
Misic, Bratislav
author_sort Hansen, Justine Y.
collection PubMed
description Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.
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spelling pubmed-96300962022-11-04 Mapping neurotransmitter systems to the structural and functional organization of the human neocortex Hansen, Justine Y. Shafiei, Golia Markello, Ross D. Smart, Kelly Cox, Sylvia M. L. Nørgaard, Martin Beliveau, Vincent Wu, Yanjun Gallezot, Jean-Dominique Aumont, Étienne Servaes, Stijn Scala, Stephanie G. DuBois, Jonathan M. Wainstein, Gabriel Bezgin, Gleb Funck, Thomas Schmitz, Taylor W. Spreng, R. Nathan Galovic, Marian Koepp, Matthias J. Duncan, John S. Coles, Jonathan P. Fryer, Tim D. Aigbirhio, Franklin I. McGinnity, Colm J. Hammers, Alexander Soucy, Jean-Paul Baillet, Sylvain Guimond, Synthia Hietala, Jarmo Bedard, Marc-André Leyton, Marco Kobayashi, Eliane Rosa-Neto, Pedro Ganz, Melanie Knudsen, Gitte M. Palomero-Gallagher, Nicola Shine, James M. Carson, Richard E. Tuominen, Lauri Dagher, Alain Misic, Bratislav Nat Neurosci Resource Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization. Nature Publishing Group US 2022-10-27 2022 /pmc/articles/PMC9630096/ /pubmed/36303070 http://dx.doi.org/10.1038/s41593-022-01186-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Resource
Hansen, Justine Y.
Shafiei, Golia
Markello, Ross D.
Smart, Kelly
Cox, Sylvia M. L.
Nørgaard, Martin
Beliveau, Vincent
Wu, Yanjun
Gallezot, Jean-Dominique
Aumont, Étienne
Servaes, Stijn
Scala, Stephanie G.
DuBois, Jonathan M.
Wainstein, Gabriel
Bezgin, Gleb
Funck, Thomas
Schmitz, Taylor W.
Spreng, R. Nathan
Galovic, Marian
Koepp, Matthias J.
Duncan, John S.
Coles, Jonathan P.
Fryer, Tim D.
Aigbirhio, Franklin I.
McGinnity, Colm J.
Hammers, Alexander
Soucy, Jean-Paul
Baillet, Sylvain
Guimond, Synthia
Hietala, Jarmo
Bedard, Marc-André
Leyton, Marco
Kobayashi, Eliane
Rosa-Neto, Pedro
Ganz, Melanie
Knudsen, Gitte M.
Palomero-Gallagher, Nicola
Shine, James M.
Carson, Richard E.
Tuominen, Lauri
Dagher, Alain
Misic, Bratislav
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
title Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
title_full Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
title_fullStr Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
title_full_unstemmed Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
title_short Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
title_sort mapping neurotransmitter systems to the structural and functional organization of the human neocortex
topic Resource
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630096/
https://www.ncbi.nlm.nih.gov/pubmed/36303070
http://dx.doi.org/10.1038/s41593-022-01186-3
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