Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression

Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute to individual clinical outcomes is unknown. Here, we compared transcriptional responses to hydrocortisone exposure in human induced pluripotent stem ce...

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Detalles Bibliográficos
Autores principales: Seah, Carina, Breen, Michael S., Rusielewicz, Tom, Bader, Heather N., Xu, Changxin, Hunter, Christopher J., McCarthy, Barry, Deans, P. J. Michael, Chattopadhyay, Mitali, Goldberg, Jordan, Desarnaud, Frank, Makotkine, Iouri, Flory, Janine D., Bierer, Linda M., Staniskyte, Migle, Noggle, Scott A., Huckins, Laura M., Paull, Daniel, Brennand, Kristen J., Yehuda, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630117/
https://www.ncbi.nlm.nih.gov/pubmed/36266471
http://dx.doi.org/10.1038/s41593-022-01161-y

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