Cargando…
Radiation dose rate effects: what is new and what is needed?
Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630203/ https://www.ncbi.nlm.nih.gov/pubmed/36241855 http://dx.doi.org/10.1007/s00411-022-00996-0 |
_version_ | 1784823549474635776 |
---|---|
author | Lowe, Donna Roy, Laurence Tabocchini, Maria Antonella Rühm, Werner Wakeford, Richard Woloschak, Gayle E. Laurier, Dominique |
author_facet | Lowe, Donna Roy, Laurence Tabocchini, Maria Antonella Rühm, Werner Wakeford, Richard Woloschak, Gayle E. Laurier, Dominique |
author_sort | Lowe, Donna |
collection | PubMed |
description | Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs. |
format | Online Article Text |
id | pubmed-9630203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-96302032022-11-04 Radiation dose rate effects: what is new and what is needed? Lowe, Donna Roy, Laurence Tabocchini, Maria Antonella Rühm, Werner Wakeford, Richard Woloschak, Gayle E. Laurier, Dominique Radiat Environ Biophys Review Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs. Springer Berlin Heidelberg 2022-10-15 2022 /pmc/articles/PMC9630203/ /pubmed/36241855 http://dx.doi.org/10.1007/s00411-022-00996-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Lowe, Donna Roy, Laurence Tabocchini, Maria Antonella Rühm, Werner Wakeford, Richard Woloschak, Gayle E. Laurier, Dominique Radiation dose rate effects: what is new and what is needed? |
title | Radiation dose rate effects: what is new and what is needed? |
title_full | Radiation dose rate effects: what is new and what is needed? |
title_fullStr | Radiation dose rate effects: what is new and what is needed? |
title_full_unstemmed | Radiation dose rate effects: what is new and what is needed? |
title_short | Radiation dose rate effects: what is new and what is needed? |
title_sort | radiation dose rate effects: what is new and what is needed? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630203/ https://www.ncbi.nlm.nih.gov/pubmed/36241855 http://dx.doi.org/10.1007/s00411-022-00996-0 |
work_keys_str_mv | AT lowedonna radiationdoserateeffectswhatisnewandwhatisneeded AT roylaurence radiationdoserateeffectswhatisnewandwhatisneeded AT tabocchinimariaantonella radiationdoserateeffectswhatisnewandwhatisneeded AT ruhmwerner radiationdoserateeffectswhatisnewandwhatisneeded AT wakefordrichard radiationdoserateeffectswhatisnewandwhatisneeded AT woloschakgaylee radiationdoserateeffectswhatisnewandwhatisneeded AT laurierdominique radiationdoserateeffectswhatisnewandwhatisneeded |