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Radiation dose rate effects: what is new and what is needed?

Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary...

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Autores principales: Lowe, Donna, Roy, Laurence, Tabocchini, Maria Antonella, Rühm, Werner, Wakeford, Richard, Woloschak, Gayle E., Laurier, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630203/
https://www.ncbi.nlm.nih.gov/pubmed/36241855
http://dx.doi.org/10.1007/s00411-022-00996-0
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author Lowe, Donna
Roy, Laurence
Tabocchini, Maria Antonella
Rühm, Werner
Wakeford, Richard
Woloschak, Gayle E.
Laurier, Dominique
author_facet Lowe, Donna
Roy, Laurence
Tabocchini, Maria Antonella
Rühm, Werner
Wakeford, Richard
Woloschak, Gayle E.
Laurier, Dominique
author_sort Lowe, Donna
collection PubMed
description Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.
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spelling pubmed-96302032022-11-04 Radiation dose rate effects: what is new and what is needed? Lowe, Donna Roy, Laurence Tabocchini, Maria Antonella Rühm, Werner Wakeford, Richard Woloschak, Gayle E. Laurier, Dominique Radiat Environ Biophys Review Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs. Springer Berlin Heidelberg 2022-10-15 2022 /pmc/articles/PMC9630203/ /pubmed/36241855 http://dx.doi.org/10.1007/s00411-022-00996-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Lowe, Donna
Roy, Laurence
Tabocchini, Maria Antonella
Rühm, Werner
Wakeford, Richard
Woloschak, Gayle E.
Laurier, Dominique
Radiation dose rate effects: what is new and what is needed?
title Radiation dose rate effects: what is new and what is needed?
title_full Radiation dose rate effects: what is new and what is needed?
title_fullStr Radiation dose rate effects: what is new and what is needed?
title_full_unstemmed Radiation dose rate effects: what is new and what is needed?
title_short Radiation dose rate effects: what is new and what is needed?
title_sort radiation dose rate effects: what is new and what is needed?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630203/
https://www.ncbi.nlm.nih.gov/pubmed/36241855
http://dx.doi.org/10.1007/s00411-022-00996-0
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