Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells

AIMS/HYPOTHESIS: CD40 expressed in Müller cells is a central driver of diabetic retinopathy. CD40 causes phospholipase Cγ1 (PLCγ1)-dependent ATP release in Müller cells followed by purinergic receptor (P2X(7))-dependent production of proinflammatory cytokines in myeloid cells. In the diabetic retina...

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Detalles Bibliográficos
Autores principales: Portillo, Jose-Andres C., Yu, Jin-Sang, Vos, Sarah, Bapputty, Reena, Lopez Corcino, Yalitza, Hubal, Alyssa, Daw, Jad, Arora, Sahil, Sun, Wenyu, Lu, Zheng-Rong, Subauste, Carlos S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630214/
https://www.ncbi.nlm.nih.gov/pubmed/35920844
http://dx.doi.org/10.1007/s00125-022-05775-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630214/
https://www.ncbi.nlm.nih.gov/pubmed/35920844
http://dx.doi.org/10.1007/s00125-022-05775-6

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