Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis

The androgen receptor (AR)-signaling pathways are essential for prostate tumorigenesis. Although significant effort has been devoted to directly targeting AR-expressing tumor cells, these therapies failed in most prostate cancer patients. Here, we demonstrate that loss of AR in stromal sonic-hedgeho...

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Detalles Bibliográficos
Autores principales: Hiroto, Alex, Kim, Won Kyung, Pineda, Ariana, He, Yongfeng, Lee, Dong-Hoon, Le, Vien, Olson, Adam W., Aldahl, Joseph, Nenninger, Christian H., Buckley, Alyssa J., Xiao, Guang-Qian, Geradts, Joseph, Sun, Zijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630272/
https://www.ncbi.nlm.nih.gov/pubmed/36323713
http://dx.doi.org/10.1038/s41467-022-34282-w

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