Computational modeling of the effect of five mutations on the structure of the ACE2 receptor and their correlation with infectivity and virulence of some emerged variants of SARS-CoV-2 suggests mechanisms of binding affinity dysregulation

Interactions between the human angiotensin-converting enzyme 2 (ACE2) and the RBD region of the SARS-CoV-2 Spike protein are critical for virus entry into the host cell. The objective of this work was to identify some of the most relevant SARS-CoV-2 Spike variants that emerged during the pandemic an...

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Detalles Bibliográficos
Autores principales: Rodriguez, J.A., Gonzalez, J., Arboleda-Bustos, C.E., Mendoza, N., Martinez, C., Pinzon, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630301/
https://www.ncbi.nlm.nih.gov/pubmed/36336003
http://dx.doi.org/10.1016/j.cbi.2022.110244

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