speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

Chimeric antigen receptors (CARs) consist of an antigen-binding region fused to intracellular signaling domains, enabling customized T cell responses against targets. Despite their major role in T cell activation, effector function and persistence, only a small set of immune signaling domains have b...

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Detalles Bibliográficos
Autores principales: Castellanos-Rueda, Rocío, Di Roberto, Raphaël B., Bieberich, Florian, Schlatter, Fabrice S., Palianina, Darya, Nguyen, Oanh T. P., Kapetanovic, Edo, Läubli, Heinz, Hierlemann, Andreas, Khanna, Nina, Reddy, Sai T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630321/
https://www.ncbi.nlm.nih.gov/pubmed/36323661
http://dx.doi.org/10.1038/s41467-022-34141-8

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