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An update on the interaction between COVID-19, vaccines, and diabetic kidney disease

Up to now, coronavirus disease 2019 (COVID-19) is still affecting worldwide due to its highly infectious nature anrapid spread. Diabetic kidney disease (DKD) is an independent risk factor for severe COVID-19 outcomes, and they have a certain correlation in some aspects. Particularly, the activated r...

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Autores principales: Yang, Yang, Zou, Shubiao, Xu, Gaosi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630353/
https://www.ncbi.nlm.nih.gov/pubmed/36341356
http://dx.doi.org/10.3389/fimmu.2022.999534
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author Yang, Yang
Zou, Shubiao
Xu, Gaosi
author_facet Yang, Yang
Zou, Shubiao
Xu, Gaosi
author_sort Yang, Yang
collection PubMed
description Up to now, coronavirus disease 2019 (COVID-19) is still affecting worldwide due to its highly infectious nature anrapid spread. Diabetic kidney disease (DKD) is an independent risk factor for severe COVID-19 outcomes, and they have a certain correlation in some aspects. Particularly, the activated renin–angiotensin–aldosterone system, chronic inflammation, endothelial dysfunction, and hypercoagulation state play an important role in the underlying mechanism linking COVID-19 to DKD. The dipeptidyl peptidase-4 inhibitor is considered a potential therapy for COVID-19 and has similarly shown organ protection in DKD. In addition, neuropilin-1 as an alternative pathway for angiotensin-converting enzyme 2 also contributes to severe acute respiratory syndrome coronavirus 2 entering the host cells, and its decreased expression can affect podocyte migration and adhesion. Here, we review the pathogenesis and current evidence of the interaction of DKD and COVID-19, as well as focus on elevated blood glucose following vaccination and its possible mechanism. Grasping the pathophysiology of DKD patients with COVID-19 is of great clinical significance for the formulation of therapeutic strategies.
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spelling pubmed-96303532022-11-04 An update on the interaction between COVID-19, vaccines, and diabetic kidney disease Yang, Yang Zou, Shubiao Xu, Gaosi Front Immunol Immunology Up to now, coronavirus disease 2019 (COVID-19) is still affecting worldwide due to its highly infectious nature anrapid spread. Diabetic kidney disease (DKD) is an independent risk factor for severe COVID-19 outcomes, and they have a certain correlation in some aspects. Particularly, the activated renin–angiotensin–aldosterone system, chronic inflammation, endothelial dysfunction, and hypercoagulation state play an important role in the underlying mechanism linking COVID-19 to DKD. The dipeptidyl peptidase-4 inhibitor is considered a potential therapy for COVID-19 and has similarly shown organ protection in DKD. In addition, neuropilin-1 as an alternative pathway for angiotensin-converting enzyme 2 also contributes to severe acute respiratory syndrome coronavirus 2 entering the host cells, and its decreased expression can affect podocyte migration and adhesion. Here, we review the pathogenesis and current evidence of the interaction of DKD and COVID-19, as well as focus on elevated blood glucose following vaccination and its possible mechanism. Grasping the pathophysiology of DKD patients with COVID-19 is of great clinical significance for the formulation of therapeutic strategies. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630353/ /pubmed/36341356 http://dx.doi.org/10.3389/fimmu.2022.999534 Text en Copyright © 2022 Yang, Zou and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yang, Yang
Zou, Shubiao
Xu, Gaosi
An update on the interaction between COVID-19, vaccines, and diabetic kidney disease
title An update on the interaction between COVID-19, vaccines, and diabetic kidney disease
title_full An update on the interaction between COVID-19, vaccines, and diabetic kidney disease
title_fullStr An update on the interaction between COVID-19, vaccines, and diabetic kidney disease
title_full_unstemmed An update on the interaction between COVID-19, vaccines, and diabetic kidney disease
title_short An update on the interaction between COVID-19, vaccines, and diabetic kidney disease
title_sort update on the interaction between covid-19, vaccines, and diabetic kidney disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630353/
https://www.ncbi.nlm.nih.gov/pubmed/36341356
http://dx.doi.org/10.3389/fimmu.2022.999534
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