Cargando…
An update on the interaction between COVID-19, vaccines, and diabetic kidney disease
Up to now, coronavirus disease 2019 (COVID-19) is still affecting worldwide due to its highly infectious nature anrapid spread. Diabetic kidney disease (DKD) is an independent risk factor for severe COVID-19 outcomes, and they have a certain correlation in some aspects. Particularly, the activated r...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630353/ https://www.ncbi.nlm.nih.gov/pubmed/36341356 http://dx.doi.org/10.3389/fimmu.2022.999534 |
_version_ | 1784823584405848064 |
---|---|
author | Yang, Yang Zou, Shubiao Xu, Gaosi |
author_facet | Yang, Yang Zou, Shubiao Xu, Gaosi |
author_sort | Yang, Yang |
collection | PubMed |
description | Up to now, coronavirus disease 2019 (COVID-19) is still affecting worldwide due to its highly infectious nature anrapid spread. Diabetic kidney disease (DKD) is an independent risk factor for severe COVID-19 outcomes, and they have a certain correlation in some aspects. Particularly, the activated renin–angiotensin–aldosterone system, chronic inflammation, endothelial dysfunction, and hypercoagulation state play an important role in the underlying mechanism linking COVID-19 to DKD. The dipeptidyl peptidase-4 inhibitor is considered a potential therapy for COVID-19 and has similarly shown organ protection in DKD. In addition, neuropilin-1 as an alternative pathway for angiotensin-converting enzyme 2 also contributes to severe acute respiratory syndrome coronavirus 2 entering the host cells, and its decreased expression can affect podocyte migration and adhesion. Here, we review the pathogenesis and current evidence of the interaction of DKD and COVID-19, as well as focus on elevated blood glucose following vaccination and its possible mechanism. Grasping the pathophysiology of DKD patients with COVID-19 is of great clinical significance for the formulation of therapeutic strategies. |
format | Online Article Text |
id | pubmed-9630353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96303532022-11-04 An update on the interaction between COVID-19, vaccines, and diabetic kidney disease Yang, Yang Zou, Shubiao Xu, Gaosi Front Immunol Immunology Up to now, coronavirus disease 2019 (COVID-19) is still affecting worldwide due to its highly infectious nature anrapid spread. Diabetic kidney disease (DKD) is an independent risk factor for severe COVID-19 outcomes, and they have a certain correlation in some aspects. Particularly, the activated renin–angiotensin–aldosterone system, chronic inflammation, endothelial dysfunction, and hypercoagulation state play an important role in the underlying mechanism linking COVID-19 to DKD. The dipeptidyl peptidase-4 inhibitor is considered a potential therapy for COVID-19 and has similarly shown organ protection in DKD. In addition, neuropilin-1 as an alternative pathway for angiotensin-converting enzyme 2 also contributes to severe acute respiratory syndrome coronavirus 2 entering the host cells, and its decreased expression can affect podocyte migration and adhesion. Here, we review the pathogenesis and current evidence of the interaction of DKD and COVID-19, as well as focus on elevated blood glucose following vaccination and its possible mechanism. Grasping the pathophysiology of DKD patients with COVID-19 is of great clinical significance for the formulation of therapeutic strategies. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630353/ /pubmed/36341356 http://dx.doi.org/10.3389/fimmu.2022.999534 Text en Copyright © 2022 Yang, Zou and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Yang, Yang Zou, Shubiao Xu, Gaosi An update on the interaction between COVID-19, vaccines, and diabetic kidney disease |
title | An update on the interaction between COVID-19, vaccines, and diabetic kidney disease |
title_full | An update on the interaction between COVID-19, vaccines, and diabetic kidney disease |
title_fullStr | An update on the interaction between COVID-19, vaccines, and diabetic kidney disease |
title_full_unstemmed | An update on the interaction between COVID-19, vaccines, and diabetic kidney disease |
title_short | An update on the interaction between COVID-19, vaccines, and diabetic kidney disease |
title_sort | update on the interaction between covid-19, vaccines, and diabetic kidney disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630353/ https://www.ncbi.nlm.nih.gov/pubmed/36341356 http://dx.doi.org/10.3389/fimmu.2022.999534 |
work_keys_str_mv | AT yangyang anupdateontheinteractionbetweencovid19vaccinesanddiabetickidneydisease AT zoushubiao anupdateontheinteractionbetweencovid19vaccinesanddiabetickidneydisease AT xugaosi anupdateontheinteractionbetweencovid19vaccinesanddiabetickidneydisease AT yangyang updateontheinteractionbetweencovid19vaccinesanddiabetickidneydisease AT zoushubiao updateontheinteractionbetweencovid19vaccinesanddiabetickidneydisease AT xugaosi updateontheinteractionbetweencovid19vaccinesanddiabetickidneydisease |