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Detection of mitochondrial DNA mutations in circulating mitochondria-originated extracellular vesicles for potential diagnostic applications in pancreatic adenocarcinoma

There is a complete lack of highly sensitive and specific biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis, limiting multi-modal therapeutic options. Mitochondrial DNA (mtDNA) is an excellent resource for biomarker discovery because of its high copy number and increased mutatio...

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Detalles Bibliográficos
Autores principales:	Vikramdeo, Kunwar Somesh, Anand, Shashi, Khan, Mohammad Aslam, Khushman, Moh’d, Heslin, Martin J., Singh, Seema, Singh, Ajay Pratap, Dasgupta, Santanu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630429/ https://www.ncbi.nlm.nih.gov/pubmed/36323735 http://dx.doi.org/10.1038/s41598-022-22006-5

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