Cargando…

Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

The T cell receptor (TCR) expressed by T lymphocytes initiates protective immune responses to pathogens and tumors. To explore the structural basis of how TCR signaling is initiated when the receptor binds to peptide-loaded major histocompatibility complex (pMHC) molecules, we used cryogenic electro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sušac, Lukas, Vuong, Mai T., Thomas, Christoph, von Bülow, Sören, O’Brien-Ball, Caitlin, Santos, Ana Mafalda, Fernandes, Ricardo A., Hummer, Gerhard, Tampé, Robert, Davis, Simon J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630439/ https://www.ncbi.nlm.nih.gov/pubmed/35985289 http://dx.doi.org/10.1016/j.cell.2022.07.010

Ejemplares similares

TCR/pMHC Optimized Protein crystallization Screen
por: Bulek, Anna M., et al.
Publicado: (2012)

Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One
por: Khan, Javed Mohammed, et al.
Publicado: (2011)

Force Measurements of TCR/pMHC Recognition at T Cell Surface
por: Puech, Pierre-Henri, et al.
Publicado: (2011)

Genome-wide structural modelling of TCR-pMHC interactions
por: Liu, I-Hsin, et al.
Publicado: (2013)

TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma
por: Gálvez, Jesús, et al.
Publicado: (2016)

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics
por: Buckle, Ashley M., et al.
Publicado: (2018)

Rapid screening of TCR-pMHC interactions by the YAMTAD system
por: Wang, Lihui, et al.
Publicado: (2022)

Information-Driven Docking for TCR-pMHC Complex Prediction
por: Peacock, Thomas, et al.
Publicado: (2021)

Identification and isolation of high avidity tumor-specific CD8 T cells by experimentally assessing pMHC-TCR binding parameters with soluble pMHC complexes
por: Schmidt, Julien, et al.
Publicado: (2015)

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination
por: Brazin, Kristine N., et al.
Publicado: (2015)

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
por: Axmann, Markus, et al.
Publicado: (2015)

TCR–pMHC bond conformation controls TCR ligand discrimination
por: Sasmal, Dibyendu K., et al.
Publicado: (2019)

Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
por: Egan, Joseph R., et al.
Publicado: (2022)

Quantum dot/pMHC multimers vs. phycoerythrin/pMHC tetramers for identification of HLA-A*0201-restricted pHBV core antigen(18–27)-specific T cells
por: Zhu, Jianmeng, et al.
Publicado: (2017)

The kinetics of two dimensional TCR and pMHC interactions determine T cell responsiveness
por: Huang, Jun, et al.
Publicado: (2010)

A unifying mathematical framework for experimental TCR-pMHC kinetic constants
por: Faro, Jose, et al.
Publicado: (2017)

TCRpMHCmodels: Structural modelling of TCR-pMHC class I complexes
por: Jensen, Kamilla Kjærgaard, et al.
Publicado: (2019)

Immunological Mechanisms of Metal Allergies and the Nickel-Specific TCR-pMHC Interface
por: Riedel, Franziska, et al.
Publicado: (2021)

The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering
por: Shevyrev, D. V., et al.
Publicado: (2022)

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction
por: Boulter, Jonathan M, et al.
Publicado: (2007)

DockTope: a Web-based tool for automated pMHC-I modelling
por: Menegatti Rigo, Maurício, et al.
Publicado: (2015)

Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions
por: Alba, Josephine, et al.
Publicado: (2020)

A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery
por: Goldberg, Shalom D., et al.
Publicado: (2021)

Molecular basis of MHC I quality control in the peptide loading complex
por: Domnick, Alexander, et al.
Publicado: (2022)

Conformation-selective rather than avidity-based binding to tumor associated antigen derived peptide-MHC enables targeting of WT1-pMHC low expressing cancer cells by anti-WT1-pMHC/CD3 T cell engagers
por: Walseng, Even, et al.
Publicado: (2023)

Epitope Flexibility and Dynamic Footprint Revealed by Molecular Dynamics of a pMHC-TCR Complex
por: Reboul, Cyril F., et al.
Publicado: (2012)

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
por: O'Donoghue, Geoff P, et al.
Publicado: (2013)

The coordination of unprotonated peptide tertiary structure as a metric of pMHC–TCR functional avidity
por: Antipas, Georgios S.E., et al.
Publicado: (2015)

Performance comparison of TCR-pMHC prediction tools reveals a strong data dependency
por: Deng, Lihua, et al.
Publicado: (2023)

Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch
por: Blees, Andreas, et al.
Publicado: (2015)

High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange
por: Overall, Sarah A., et al.
Publicado: (2020)

MIX-TPI: a flexible prediction framework for TCR–pMHC interactions based on multimodal representations
por: Yang, Minghao, et al.
Publicado: (2023)

A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR–pMHC complexes
por: Mizsei, Réka, et al.
Publicado: (2021)

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state
por: Yachi, Pia P., et al.
Publicado: (2007)

TCR Triggering by pMHC Ligands Tethered on Surfaces via Poly(Ethylene Glycol) Depends on Polymer Length
por: Ma, Zhengyu, et al.
Publicado: (2014)

Application of the pMHC Array to Characterise Tumour Antigen Specific T Cell Populations in Leukaemia Patients at Disease Diagnosis
por: Brooks, Suzanne E., et al.
Publicado: (2015)

Intramolecular Domain Movements of Free and Bound pMHC and TCR Proteins: A Molecular Dynamics Simulation Study
por: Karch, Rudolf, et al.
Publicado: (2019)

Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck
por: Zhao, Xiang, et al.
Publicado: (2021)

Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8(+) T cell detection
por: Sun, Yueyang, et al.
Publicado: (2022)

Simulation of FUS Protein Condensates with an Adapted Coarse-Grained Model
por: Benayad, Zakarya, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hjc21oudb77tsjrlca296q5nlp