Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency

Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotype due to the accumulation of CpG>TpG transitions. Here,...

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Detalles Bibliográficos
Autores principales: Chabot, Thomas, Nemati, Fariba, Herbette, Aurélie, Demeyer, Alexandre, Dayot, Stéphane, Ganier, Olivier, Alsafadi, Samar, Gardrat, Sophie, Mariani, Pascale, Luporsi, Marie, Corbé, Maxime, Servois, Vincent, Cassoux, Nathalie, Decaudin, Didier, Roman, Sergio Roman, Del Nery, Elaine, Piperno-Neumann, Sophie, Stern, Marc-Henri, Rodrigues, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630501/
https://www.ncbi.nlm.nih.gov/pubmed/36323843
http://dx.doi.org/10.1038/s41698-022-00326-z

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