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Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis

In breast conserving surgery (BCS), specimen mammography is one of the most widely used intraoperative methods of assessing margin status. We performed a meta-analysis to evaluate the diagnostic accuracy of specimen mammography. Literature databases including PubMed, Cochrane Library, Web of Science...

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Autores principales: Lin, Chen, Wang, Kai-yue, Chen, Hai-lang, Xu, Yu-hua, Pan, Tao, Chen, Yi-ding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630505/
https://www.ncbi.nlm.nih.gov/pubmed/36323863
http://dx.doi.org/10.1038/s41598-022-23234-5
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author Lin, Chen
Wang, Kai-yue
Chen, Hai-lang
Xu, Yu-hua
Pan, Tao
Chen, Yi-ding
author_facet Lin, Chen
Wang, Kai-yue
Chen, Hai-lang
Xu, Yu-hua
Pan, Tao
Chen, Yi-ding
author_sort Lin, Chen
collection PubMed
description In breast conserving surgery (BCS), specimen mammography is one of the most widely used intraoperative methods of assessing margin status. We performed a meta-analysis to evaluate the diagnostic accuracy of specimen mammography. Literature databases including PubMed, Cochrane Library, Web of Science, and EMBASE were searched prior to Jun 2022. A total of 1967 patients were included from 20 studies. A pooled analysis, heterogeneity testing, threshold effect testing, publication bias analysis, and subgroup analyses were performed from extracted data. The pooled weighted values were a sensitivity of 0.55 (95% confidence interval [CI], 0.47–0.63), a specificity of 0.85 (95% CI, 0.78–0.90), a diagnostic odds ratio of 7 (95% CI, 4–12), and a pooled positive likelihood ratio of 3.7 (95% CI 2.6–5.5). The area under the receiver operator characteristic curve was 0.75 (95% CI 0.71–0.78). In the subgroup analysis, the pooled specificity in the positive margin defined as tumor at margin subgroup was lower than the other positive margin definition subgroup (0.82 [95% CI: 0.71, 0.92] vs. 0.87 [95% CI: 0.80, 0.94], p = 0.01). Our findings indicated that specimen mammography was an accurate intraoperative imaging technique for margin assessment in BCS.
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spelling pubmed-96305052022-11-04 Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis Lin, Chen Wang, Kai-yue Chen, Hai-lang Xu, Yu-hua Pan, Tao Chen, Yi-ding Sci Rep Article In breast conserving surgery (BCS), specimen mammography is one of the most widely used intraoperative methods of assessing margin status. We performed a meta-analysis to evaluate the diagnostic accuracy of specimen mammography. Literature databases including PubMed, Cochrane Library, Web of Science, and EMBASE were searched prior to Jun 2022. A total of 1967 patients were included from 20 studies. A pooled analysis, heterogeneity testing, threshold effect testing, publication bias analysis, and subgroup analyses were performed from extracted data. The pooled weighted values were a sensitivity of 0.55 (95% confidence interval [CI], 0.47–0.63), a specificity of 0.85 (95% CI, 0.78–0.90), a diagnostic odds ratio of 7 (95% CI, 4–12), and a pooled positive likelihood ratio of 3.7 (95% CI 2.6–5.5). The area under the receiver operator characteristic curve was 0.75 (95% CI 0.71–0.78). In the subgroup analysis, the pooled specificity in the positive margin defined as tumor at margin subgroup was lower than the other positive margin definition subgroup (0.82 [95% CI: 0.71, 0.92] vs. 0.87 [95% CI: 0.80, 0.94], p = 0.01). Our findings indicated that specimen mammography was an accurate intraoperative imaging technique for margin assessment in BCS. Nature Publishing Group UK 2022-11-02 /pmc/articles/PMC9630505/ /pubmed/36323863 http://dx.doi.org/10.1038/s41598-022-23234-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lin, Chen
Wang, Kai-yue
Chen, Hai-lang
Xu, Yu-hua
Pan, Tao
Chen, Yi-ding
Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis
title Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis
title_full Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis
title_fullStr Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis
title_full_unstemmed Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis
title_short Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis
title_sort specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630505/
https://www.ncbi.nlm.nih.gov/pubmed/36323863
http://dx.doi.org/10.1038/s41598-022-23234-5
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