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Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health

Aging is a gradual and progressive deterioration of integrity across multiple organ systems that negatively affects gingival wound healing. The cellular responses associated with wound healing, such as collagen synthesis, cell migration, proliferation, and collagen contraction, have been shown to be...

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Autores principales: Villalobos, Verónica, Garrido, Mauricio, Reyes, Antonia, Fernández, Christian, Diaz, Catalina, Torres, Vicente A., González, Pablo A., Cáceres, Mónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630574/
https://www.ncbi.nlm.nih.gov/pubmed/36341447
http://dx.doi.org/10.3389/fimmu.2022.1044334
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author Villalobos, Verónica
Garrido, Mauricio
Reyes, Antonia
Fernández, Christian
Diaz, Catalina
Torres, Vicente A.
González, Pablo A.
Cáceres, Mónica
author_facet Villalobos, Verónica
Garrido, Mauricio
Reyes, Antonia
Fernández, Christian
Diaz, Catalina
Torres, Vicente A.
González, Pablo A.
Cáceres, Mónica
author_sort Villalobos, Verónica
collection PubMed
description Aging is a gradual and progressive deterioration of integrity across multiple organ systems that negatively affects gingival wound healing. The cellular responses associated with wound healing, such as collagen synthesis, cell migration, proliferation, and collagen contraction, have been shown to be lower in gingival fibroblasts (the most abundant cells from the connective gingival tissue) in aged donors than young donors. Cellular senescence is one of the hallmarks of aging, which is characterized by the acquisition of a senescence-associated secretory phenotype that is characterized by the release of pro-inflammatory cytokines, chemokines, growth factors, and proteases which have been implicated in the recruitment of immune cells such as neutrophils, T cells and monocytes. Moreover, during aging, macrophages show altered acquisition of functional phenotypes in response to the tissue microenvironment. Thus, inflammatory and resolution macrophage-mediated processes are impaired, impacting the progression of periodontal disease. Interestingly, salivary antimicrobial peptides, such as histatins, which are involved in various functions, such as antifungal, bactericidal, enamel-protecting, angiogenesis, and re-epithelization, have been shown to fluctuate with aging. Several studies have associated the presence of Porphyromonas gingivalis, a key pathogen related to periodontitis and apical periodontitis, with the progression of Alzheimer’s disease, as well as gut, esophageal, and gastric cancers. Moreover, herpes simplex virus types 1 and 2 have been associated with the severity of periodontal disease, cardiovascular complications, and nervous system-related pathologies. This review encompasses the effects of aging on periodontal tissues, how P. gingivalis and HSV infections could favor periodontitis and their relationship with other pathologies.
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spelling pubmed-96305742022-11-04 Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health Villalobos, Verónica Garrido, Mauricio Reyes, Antonia Fernández, Christian Diaz, Catalina Torres, Vicente A. González, Pablo A. Cáceres, Mónica Front Immunol Immunology Aging is a gradual and progressive deterioration of integrity across multiple organ systems that negatively affects gingival wound healing. The cellular responses associated with wound healing, such as collagen synthesis, cell migration, proliferation, and collagen contraction, have been shown to be lower in gingival fibroblasts (the most abundant cells from the connective gingival tissue) in aged donors than young donors. Cellular senescence is one of the hallmarks of aging, which is characterized by the acquisition of a senescence-associated secretory phenotype that is characterized by the release of pro-inflammatory cytokines, chemokines, growth factors, and proteases which have been implicated in the recruitment of immune cells such as neutrophils, T cells and monocytes. Moreover, during aging, macrophages show altered acquisition of functional phenotypes in response to the tissue microenvironment. Thus, inflammatory and resolution macrophage-mediated processes are impaired, impacting the progression of periodontal disease. Interestingly, salivary antimicrobial peptides, such as histatins, which are involved in various functions, such as antifungal, bactericidal, enamel-protecting, angiogenesis, and re-epithelization, have been shown to fluctuate with aging. Several studies have associated the presence of Porphyromonas gingivalis, a key pathogen related to periodontitis and apical periodontitis, with the progression of Alzheimer’s disease, as well as gut, esophageal, and gastric cancers. Moreover, herpes simplex virus types 1 and 2 have been associated with the severity of periodontal disease, cardiovascular complications, and nervous system-related pathologies. This review encompasses the effects of aging on periodontal tissues, how P. gingivalis and HSV infections could favor periodontitis and their relationship with other pathologies. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630574/ /pubmed/36341447 http://dx.doi.org/10.3389/fimmu.2022.1044334 Text en Copyright © 2022 Villalobos, Garrido, Reyes, Fernández, Diaz, Torres, González and Cáceres https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Villalobos, Verónica
Garrido, Mauricio
Reyes, Antonia
Fernández, Christian
Diaz, Catalina
Torres, Vicente A.
González, Pablo A.
Cáceres, Mónica
Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health
title Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health
title_full Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health
title_fullStr Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health
title_full_unstemmed Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health
title_short Aging envisage imbalance of the periodontium: A keystone in oral disease and systemic health
title_sort aging envisage imbalance of the periodontium: a keystone in oral disease and systemic health
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630574/
https://www.ncbi.nlm.nih.gov/pubmed/36341447
http://dx.doi.org/10.3389/fimmu.2022.1044334
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