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Effects of high altitude on renal physiology and kidney diseases
The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply (20%–25% of cardiac output) and high blood flow; thus, they are susceptible to the effects of hypoxia. However, the effects...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630589/ https://www.ncbi.nlm.nih.gov/pubmed/36338473 http://dx.doi.org/10.3389/fphys.2022.969456 |
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author | Wang, Si-Yang Gao, Jie Zhao, Jing-Hong |
author_facet | Wang, Si-Yang Gao, Jie Zhao, Jing-Hong |
author_sort | Wang, Si-Yang |
collection | PubMed |
description | The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply (20%–25% of cardiac output) and high blood flow; thus, they are susceptible to the effects of hypoxia. However, the effects of acute and chronic exposure to high altitudes on renal physiology and pathology are not fully understood. Moreover, few studies have investigated the impact of high-altitude exposure on patients with chronic kidney disease or acute kidney injury. In this review, we summarized changes in renal physiology and renal pathology due to high-altitude exposure as well as the impact of high-altitude exposure on existing kidney diseases, with the aim of informing the prevention and treatment of kidney diseases at high altitudes. |
format | Online Article Text |
id | pubmed-9630589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96305892022-11-04 Effects of high altitude on renal physiology and kidney diseases Wang, Si-Yang Gao, Jie Zhao, Jing-Hong Front Physiol Physiology The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply (20%–25% of cardiac output) and high blood flow; thus, they are susceptible to the effects of hypoxia. However, the effects of acute and chronic exposure to high altitudes on renal physiology and pathology are not fully understood. Moreover, few studies have investigated the impact of high-altitude exposure on patients with chronic kidney disease or acute kidney injury. In this review, we summarized changes in renal physiology and renal pathology due to high-altitude exposure as well as the impact of high-altitude exposure on existing kidney diseases, with the aim of informing the prevention and treatment of kidney diseases at high altitudes. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630589/ /pubmed/36338473 http://dx.doi.org/10.3389/fphys.2022.969456 Text en Copyright © 2022 Wang, Gao and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Wang, Si-Yang Gao, Jie Zhao, Jing-Hong Effects of high altitude on renal physiology and kidney diseases |
title | Effects of high altitude on renal physiology and kidney diseases |
title_full | Effects of high altitude on renal physiology and kidney diseases |
title_fullStr | Effects of high altitude on renal physiology and kidney diseases |
title_full_unstemmed | Effects of high altitude on renal physiology and kidney diseases |
title_short | Effects of high altitude on renal physiology and kidney diseases |
title_sort | effects of high altitude on renal physiology and kidney diseases |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630589/ https://www.ncbi.nlm.nih.gov/pubmed/36338473 http://dx.doi.org/10.3389/fphys.2022.969456 |
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