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Effects of high altitude on renal physiology and kidney diseases

The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply (20%–25% of cardiac output) and high blood flow; thus, they are susceptible to the effects of hypoxia. However, the effects...

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Autores principales: Wang, Si-Yang, Gao, Jie, Zhao, Jing-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630589/
https://www.ncbi.nlm.nih.gov/pubmed/36338473
http://dx.doi.org/10.3389/fphys.2022.969456
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author Wang, Si-Yang
Gao, Jie
Zhao, Jing-Hong
author_facet Wang, Si-Yang
Gao, Jie
Zhao, Jing-Hong
author_sort Wang, Si-Yang
collection PubMed
description The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply (20%–25% of cardiac output) and high blood flow; thus, they are susceptible to the effects of hypoxia. However, the effects of acute and chronic exposure to high altitudes on renal physiology and pathology are not fully understood. Moreover, few studies have investigated the impact of high-altitude exposure on patients with chronic kidney disease or acute kidney injury. In this review, we summarized changes in renal physiology and renal pathology due to high-altitude exposure as well as the impact of high-altitude exposure on existing kidney diseases, with the aim of informing the prevention and treatment of kidney diseases at high altitudes.
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spelling pubmed-96305892022-11-04 Effects of high altitude on renal physiology and kidney diseases Wang, Si-Yang Gao, Jie Zhao, Jing-Hong Front Physiol Physiology The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have an abundant blood supply (20%–25% of cardiac output) and high blood flow; thus, they are susceptible to the effects of hypoxia. However, the effects of acute and chronic exposure to high altitudes on renal physiology and pathology are not fully understood. Moreover, few studies have investigated the impact of high-altitude exposure on patients with chronic kidney disease or acute kidney injury. In this review, we summarized changes in renal physiology and renal pathology due to high-altitude exposure as well as the impact of high-altitude exposure on existing kidney diseases, with the aim of informing the prevention and treatment of kidney diseases at high altitudes. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630589/ /pubmed/36338473 http://dx.doi.org/10.3389/fphys.2022.969456 Text en Copyright © 2022 Wang, Gao and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wang, Si-Yang
Gao, Jie
Zhao, Jing-Hong
Effects of high altitude on renal physiology and kidney diseases
title Effects of high altitude on renal physiology and kidney diseases
title_full Effects of high altitude on renal physiology and kidney diseases
title_fullStr Effects of high altitude on renal physiology and kidney diseases
title_full_unstemmed Effects of high altitude on renal physiology and kidney diseases
title_short Effects of high altitude on renal physiology and kidney diseases
title_sort effects of high altitude on renal physiology and kidney diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630589/
https://www.ncbi.nlm.nih.gov/pubmed/36338473
http://dx.doi.org/10.3389/fphys.2022.969456
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