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The potential influence of interferon-α on the growth of the growing teratoma: A case report
Growing teratoma syndrome (GTS) is rare. It is fatal if the teratoma is unresectable. A standard systemic therapy is not established. The efficacy of interferon-alpha (IFN-α) for GTS was described but the treatment periods were relatively short. A 23-year-old Japanese male with bulky retroperitoneal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630618/ https://www.ncbi.nlm.nih.gov/pubmed/36337171 http://dx.doi.org/10.1016/j.eucr.2022.102266 |
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author | Katami, Akinobu Hisasue, Shin-Ichi Sakurai, Hiromichi Kawai, Koji Hayashi, Yuichiro Miyazaki, Jun |
author_facet | Katami, Akinobu Hisasue, Shin-Ichi Sakurai, Hiromichi Kawai, Koji Hayashi, Yuichiro Miyazaki, Jun |
author_sort | Katami, Akinobu |
collection | PubMed |
description | Growing teratoma syndrome (GTS) is rare. It is fatal if the teratoma is unresectable. A standard systemic therapy is not established. The efficacy of interferon-alpha (IFN-α) for GTS was described but the treatment periods were relatively short. A 23-year-old Japanese male with bulky retroperitoneal lymph node and multiple lung metastases that progressed to GTS was administered 6 × 10(6) units of natural IFN-α 2 × /week. Since the IFN-α treatment suppressed both lesions' growth, it was continued for >10 years. The patient is well with controlled metastases (135 months since the IFN-α′s initiation). This is apparently the longest follow-up of INF-α treatment for GTS. |
format | Online Article Text |
id | pubmed-9630618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96306182022-11-04 The potential influence of interferon-α on the growth of the growing teratoma: A case report Katami, Akinobu Hisasue, Shin-Ichi Sakurai, Hiromichi Kawai, Koji Hayashi, Yuichiro Miyazaki, Jun Urol Case Rep Oncology Growing teratoma syndrome (GTS) is rare. It is fatal if the teratoma is unresectable. A standard systemic therapy is not established. The efficacy of interferon-alpha (IFN-α) for GTS was described but the treatment periods were relatively short. A 23-year-old Japanese male with bulky retroperitoneal lymph node and multiple lung metastases that progressed to GTS was administered 6 × 10(6) units of natural IFN-α 2 × /week. Since the IFN-α treatment suppressed both lesions' growth, it was continued for >10 years. The patient is well with controlled metastases (135 months since the IFN-α′s initiation). This is apparently the longest follow-up of INF-α treatment for GTS. Elsevier 2022-10-26 /pmc/articles/PMC9630618/ /pubmed/36337171 http://dx.doi.org/10.1016/j.eucr.2022.102266 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Oncology Katami, Akinobu Hisasue, Shin-Ichi Sakurai, Hiromichi Kawai, Koji Hayashi, Yuichiro Miyazaki, Jun The potential influence of interferon-α on the growth of the growing teratoma: A case report |
title | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
title_full | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
title_fullStr | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
title_full_unstemmed | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
title_short | The potential influence of interferon-α on the growth of the growing teratoma: A case report |
title_sort | potential influence of interferon-α on the growth of the growing teratoma: a case report |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630618/ https://www.ncbi.nlm.nih.gov/pubmed/36337171 http://dx.doi.org/10.1016/j.eucr.2022.102266 |
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