Analysis of thermally driven structural changes, genome release, disassembly, and aggregation of recombinant AAV by CDMS

Charge detection mass spectrometry (CDMS) was used to analyze recombinant adeno-associated virus serotype 8 (rAAV8) vectors after incubation at elevated temperatures. rAAV8 vectors with a range of genomes of interest (GOIs) from 2.22 to 4.84 kb were investigated. For the shorter GOIs, GOI release oc...

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Detalles Bibliográficos
Autores principales: Barnes, Lauren F., Draper, Benjamin E., Jarrold, Martin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630626/
https://www.ncbi.nlm.nih.gov/pubmed/36381304
http://dx.doi.org/10.1016/j.omtm.2022.10.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630626/
https://www.ncbi.nlm.nih.gov/pubmed/36381304
http://dx.doi.org/10.1016/j.omtm.2022.10.008

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