Ancestral archaea expanded the genetic code with pyrrolysine

The pyrrolysyl-tRNA synthetase (PylRS) facilitates the cotranslational installation of the 22nd amino acid pyrrolysine. Owing to its tolerance for diverse amino acid substrates, and its orthogonality in multiple organisms, PylRS has emerged as a major route to install noncanonical amino acids into p...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Li-Tao, Amikura, Kazuaki, Jiang, Han-Kai, Mukai, Takahito, Fu, Xian, Wang, Yane-Shih, O’Donoghue, Patrick, Söll, Dieter, Tharp, Jeffery M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630628/
https://www.ncbi.nlm.nih.gov/pubmed/36152750
http://dx.doi.org/10.1016/j.jbc.2022.102521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630628/
https://www.ncbi.nlm.nih.gov/pubmed/36152750
http://dx.doi.org/10.1016/j.jbc.2022.102521

Ejemplares similares