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Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review
BACKGROUND: Anti-Contactin-associated protein-like 2 (CASPR2) antibody-associated encephalitis is a rare group of autoimmune diseases that causes extensive damage to the central and/or peripheral nervous system. CASE PRESENTATION: Here, we reported a case of anti-CASPR2 antibody-associated encephali...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630637/ https://www.ncbi.nlm.nih.gov/pubmed/36340710 http://dx.doi.org/10.3389/fped.2022.1004210 |
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author | Dou, Qingyang Li, Renke Shu, Xiaomei |
author_facet | Dou, Qingyang Li, Renke Shu, Xiaomei |
author_sort | Dou, Qingyang |
collection | PubMed |
description | BACKGROUND: Anti-Contactin-associated protein-like 2 (CASPR2) antibody-associated encephalitis is a rare group of autoimmune diseases that causes extensive damage to the central and/or peripheral nervous system. CASE PRESENTATION: Here, we reported a case of anti-CASPR2 antibody-associated encephalitis in a 12-year-old male patient with symptoms of headache, consciousness disturbance, mental abnormalities, urinary incontinence, fasciculations in the extremity muscles, and involuntary movements. The testing for autoimmune encephalitis-associated antibodies showed that CASPR2-associated antibodies were positive, and electroencephalography showed diffuse slow waves. No tumor was found after screening for malignancies. The child's status significantly improved after receiving immunotherapy with intravenous methylprednisolone and immunoglobulin. CONCLUSIONS: Anti-CASPR2 antibody-associated encephalitis has been rarely reported in children. It has a complex clinical presentation and a low incidence of tumor. Most pediatric patients have a favorable prognosis and relapse is uncommon. |
format | Online Article Text |
id | pubmed-9630637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96306372022-11-04 Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review Dou, Qingyang Li, Renke Shu, Xiaomei Front Pediatr Pediatrics BACKGROUND: Anti-Contactin-associated protein-like 2 (CASPR2) antibody-associated encephalitis is a rare group of autoimmune diseases that causes extensive damage to the central and/or peripheral nervous system. CASE PRESENTATION: Here, we reported a case of anti-CASPR2 antibody-associated encephalitis in a 12-year-old male patient with symptoms of headache, consciousness disturbance, mental abnormalities, urinary incontinence, fasciculations in the extremity muscles, and involuntary movements. The testing for autoimmune encephalitis-associated antibodies showed that CASPR2-associated antibodies were positive, and electroencephalography showed diffuse slow waves. No tumor was found after screening for malignancies. The child's status significantly improved after receiving immunotherapy with intravenous methylprednisolone and immunoglobulin. CONCLUSIONS: Anti-CASPR2 antibody-associated encephalitis has been rarely reported in children. It has a complex clinical presentation and a low incidence of tumor. Most pediatric patients have a favorable prognosis and relapse is uncommon. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630637/ /pubmed/36340710 http://dx.doi.org/10.3389/fped.2022.1004210 Text en © 2022 Dou, Li and Shu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Dou, Qingyang Li, Renke Shu, Xiaomei Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review |
title | Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review |
title_full | Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review |
title_fullStr | Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review |
title_full_unstemmed | Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review |
title_short | Anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: A case report and literature review |
title_sort | anti-contactin-associated protein-like 2 antibody-associated encephalitis in children: a case report and literature review |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630637/ https://www.ncbi.nlm.nih.gov/pubmed/36340710 http://dx.doi.org/10.3389/fped.2022.1004210 |
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