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Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives

Acupuncture is commonly used as a treatment for migraines. Animal studies have suggested that acupuncture can decrease neuropeptides, immune cells, and proinflammatory and excitatory neurotransmitters, which are associated with the pathogenesis of neuroinflammation. In addition, acupuncture particip...

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Autores principales: Chen, Ying, Liu, Yuhan, Song, Yine, Zhao, Shaoru, Li, Bin, Sun, Jingqing, Liu, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630645/
https://www.ncbi.nlm.nih.gov/pubmed/36340786
http://dx.doi.org/10.3389/fnins.2022.1022455
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author Chen, Ying
Liu, Yuhan
Song, Yine
Zhao, Shaoru
Li, Bin
Sun, Jingqing
Liu, Lu
author_facet Chen, Ying
Liu, Yuhan
Song, Yine
Zhao, Shaoru
Li, Bin
Sun, Jingqing
Liu, Lu
author_sort Chen, Ying
collection PubMed
description Acupuncture is commonly used as a treatment for migraines. Animal studies have suggested that acupuncture can decrease neuropeptides, immune cells, and proinflammatory and excitatory neurotransmitters, which are associated with the pathogenesis of neuroinflammation. In addition, acupuncture participates in the development of peripheral and central sensitization through modulation of the release of neuronal-sensitization-related mediators (brain-derived neurotrophic factor, glutamate), endocannabinoid system, and serotonin system activation. Clinical studies have demonstrated that acupuncture may be a beneficial migraine treatment, particularly in decreasing pain intensity, duration, emotional comorbidity, and days of acute medication intake. However, specific clinical effectiveness has not been substantiated, and the mechanisms underlying its efficacy remain obscure. With the development of biomedical and neuroimaging techniques, the neural mechanism of acupuncture in migraine has gained increasing attention. Neuroimaging studies have indicated that acupuncture may alter the abnormal functional activity and connectivity of the descending pain modulatory system, default mode network, thalamus, frontal-parietal network, occipital-temporal network, and cerebellum. Acupuncture may reduce neuroinflammation, regulate peripheral and central sensitization, and normalize abnormal brain activity, thereby preventing pain signal transmission. To summarize the effects and neural mechanisms of acupuncture in migraine, we performed a systematic review of literature about migraine and acupuncture. We summarized the characteristics of current clinical studies, including the types of participants, study designs, and clinical outcomes. The published findings from basic neuroimaging studies support the hypothesis that acupuncture alters abnormal neuroplasticity and brain activity. The benefits of acupuncture require further investigation through basic and clinical studies.
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spelling pubmed-96306452022-11-04 Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives Chen, Ying Liu, Yuhan Song, Yine Zhao, Shaoru Li, Bin Sun, Jingqing Liu, Lu Front Neurosci Neuroscience Acupuncture is commonly used as a treatment for migraines. Animal studies have suggested that acupuncture can decrease neuropeptides, immune cells, and proinflammatory and excitatory neurotransmitters, which are associated with the pathogenesis of neuroinflammation. In addition, acupuncture participates in the development of peripheral and central sensitization through modulation of the release of neuronal-sensitization-related mediators (brain-derived neurotrophic factor, glutamate), endocannabinoid system, and serotonin system activation. Clinical studies have demonstrated that acupuncture may be a beneficial migraine treatment, particularly in decreasing pain intensity, duration, emotional comorbidity, and days of acute medication intake. However, specific clinical effectiveness has not been substantiated, and the mechanisms underlying its efficacy remain obscure. With the development of biomedical and neuroimaging techniques, the neural mechanism of acupuncture in migraine has gained increasing attention. Neuroimaging studies have indicated that acupuncture may alter the abnormal functional activity and connectivity of the descending pain modulatory system, default mode network, thalamus, frontal-parietal network, occipital-temporal network, and cerebellum. Acupuncture may reduce neuroinflammation, regulate peripheral and central sensitization, and normalize abnormal brain activity, thereby preventing pain signal transmission. To summarize the effects and neural mechanisms of acupuncture in migraine, we performed a systematic review of literature about migraine and acupuncture. We summarized the characteristics of current clinical studies, including the types of participants, study designs, and clinical outcomes. The published findings from basic neuroimaging studies support the hypothesis that acupuncture alters abnormal neuroplasticity and brain activity. The benefits of acupuncture require further investigation through basic and clinical studies. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630645/ /pubmed/36340786 http://dx.doi.org/10.3389/fnins.2022.1022455 Text en Copyright © 2022 Chen, Liu, Song, Zhao, Li, Sun and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chen, Ying
Liu, Yuhan
Song, Yine
Zhao, Shaoru
Li, Bin
Sun, Jingqing
Liu, Lu
Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives
title Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives
title_full Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives
title_fullStr Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives
title_full_unstemmed Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives
title_short Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives
title_sort therapeutic applications and potential mechanisms of acupuncture in migraine: a literature review and perspectives
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630645/
https://www.ncbi.nlm.nih.gov/pubmed/36340786
http://dx.doi.org/10.3389/fnins.2022.1022455
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