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Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)

Using common carp as a model, we assessed the effects of polyethylene (PE) plastics on the brain. We measured activity of acetylcholinesterase (AChE), monoamine oxidase (MAO), and the content of nitric oxide (NO) in carp brain following exposure to 100 mg/L of either macroplastics (MaP), microplasti...

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Autores principales: Hamed, Mohamed, Martyniuk, Christopher J., Naguib, Mervat, Lee, Jae-Seong, Sayed, Alaa El-Din H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630652/
https://www.ncbi.nlm.nih.gov/pubmed/36340695
http://dx.doi.org/10.3389/fnmol.2022.1028364
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author Hamed, Mohamed
Martyniuk, Christopher J.
Naguib, Mervat
Lee, Jae-Seong
Sayed, Alaa El-Din H.
author_facet Hamed, Mohamed
Martyniuk, Christopher J.
Naguib, Mervat
Lee, Jae-Seong
Sayed, Alaa El-Din H.
author_sort Hamed, Mohamed
collection PubMed
description Using common carp as a model, we assessed the effects of polyethylene (PE) plastics on the brain. We measured activity of acetylcholinesterase (AChE), monoamine oxidase (MAO), and the content of nitric oxide (NO) in carp brain following exposure to 100 mg/L of either macroplastics (MaP), microplastics (MPs), or nanoplastic (NPs) for 15 days compared to an unexposed group. Following exposure, each biochemical biomarker was reduced 30–40%, with a higher magnitude of change corresponding to the smaller size of the particles (NPs > MPs > MaPs). In the carp tectum, exposure for 15 days to plastic particles caused varying degrees of necrosis, fibrosis, changes in blood capillaries, tissue detachment, edema, degenerated connective tissues, and necrosis in large cerebellar neurons and ganglion cells. In the carp retina, there was evidence for necrosis, degeneration, vacuolation, and curvature in the inner layer. Here we provide evidence that exposure to plastic particles can be associated with neurotoxicity in common carp.
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spelling pubmed-96306522022-11-04 Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio) Hamed, Mohamed Martyniuk, Christopher J. Naguib, Mervat Lee, Jae-Seong Sayed, Alaa El-Din H. Front Mol Neurosci Molecular Neuroscience Using common carp as a model, we assessed the effects of polyethylene (PE) plastics on the brain. We measured activity of acetylcholinesterase (AChE), monoamine oxidase (MAO), and the content of nitric oxide (NO) in carp brain following exposure to 100 mg/L of either macroplastics (MaP), microplastics (MPs), or nanoplastic (NPs) for 15 days compared to an unexposed group. Following exposure, each biochemical biomarker was reduced 30–40%, with a higher magnitude of change corresponding to the smaller size of the particles (NPs > MPs > MaPs). In the carp tectum, exposure for 15 days to plastic particles caused varying degrees of necrosis, fibrosis, changes in blood capillaries, tissue detachment, edema, degenerated connective tissues, and necrosis in large cerebellar neurons and ganglion cells. In the carp retina, there was evidence for necrosis, degeneration, vacuolation, and curvature in the inner layer. Here we provide evidence that exposure to plastic particles can be associated with neurotoxicity in common carp. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630652/ /pubmed/36340695 http://dx.doi.org/10.3389/fnmol.2022.1028364 Text en Copyright © 2022 Hamed, Martyniuk, Naguib, Lee and Sayed. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Hamed, Mohamed
Martyniuk, Christopher J.
Naguib, Mervat
Lee, Jae-Seong
Sayed, Alaa El-Din H.
Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)
title Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)
title_full Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)
title_fullStr Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)
title_full_unstemmed Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)
title_short Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)
title_sort neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (cyprinus carpio)
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630652/
https://www.ncbi.nlm.nih.gov/pubmed/36340695
http://dx.doi.org/10.3389/fnmol.2022.1028364
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