Cargando…
The early stage of COVID-19 pandemic: Gastrointestinal manifestations and liver injury in COVID-19 patients in Wuhan, China
There are few and inconsistent data focusing on gastrointestinal (GI) manifestations and liver injury in China's early stage of COVID-19 pandemic. In this study, we research the prevalence and role of GI symptoms and liver injury in COVID-19 patients in Wuhan during the disease's first out...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630730/ https://www.ncbi.nlm.nih.gov/pubmed/36341271 http://dx.doi.org/10.3389/fmed.2022.997000 |
_version_ | 1784823669307998208 |
---|---|
author | Chen, Dafan Ning, Min Feng, Yun Liu, Jun |
author_facet | Chen, Dafan Ning, Min Feng, Yun Liu, Jun |
author_sort | Chen, Dafan |
collection | PubMed |
description | There are few and inconsistent data focusing on gastrointestinal (GI) manifestations and liver injury in China's early stage of COVID-19 pandemic. In this study, we research the prevalence and role of GI symptoms and liver injury in COVID-19 patients in Wuhan during the disease's first outbreak. We conducted a cross-sectional observational study in a non-ICU unit in Wuhan, China. COVID-19 patients were consecutively admitted from 23 February 2020 to 5 April 2020. Demographic and clinical data were retrieved and analyzed throughout the disease course. A total of 93 patients were enrolled, including 45.2% moderate, 54.8% severe, and 2.2% critical type patients. 69.9% of patients had at least one GI symptom; if excluding hyporexia/anorexia, 49.5% of patients showed at least one GI symptom. The incidence rate of hyporexia/anorexia, diarrhea, nausea/vomiting, abdominal discomfort/pain, and elevated liver enzymes were 67.7, 29.0, 28.0, 21.5, and 23.7%, respectively. Patients with GI symptoms or elevated liver enzymes have a higher risk of severe type disease than patients without GI symptoms or elevated liver enzymes (67.7 vs. 25.0%, p < 0.001; 77.3 vs. 47.9%, p = 0.016, respectively), and experienced longer disease duration. In multivariate analysis, hyporexia/anorexia was confirmed as an independent predictive factor of severe type disease (odds ratio: 5.912; 95% confidence interval: 2.247–15.559; p < 0.001). In conclusion, in the early stage of the COVID-19 pandemic, GI symptoms and elevated liver enzymes are common throughout the disease course, and associated with severer disease and longer disease duration. |
format | Online Article Text |
id | pubmed-9630730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96307302022-11-04 The early stage of COVID-19 pandemic: Gastrointestinal manifestations and liver injury in COVID-19 patients in Wuhan, China Chen, Dafan Ning, Min Feng, Yun Liu, Jun Front Med (Lausanne) Medicine There are few and inconsistent data focusing on gastrointestinal (GI) manifestations and liver injury in China's early stage of COVID-19 pandemic. In this study, we research the prevalence and role of GI symptoms and liver injury in COVID-19 patients in Wuhan during the disease's first outbreak. We conducted a cross-sectional observational study in a non-ICU unit in Wuhan, China. COVID-19 patients were consecutively admitted from 23 February 2020 to 5 April 2020. Demographic and clinical data were retrieved and analyzed throughout the disease course. A total of 93 patients were enrolled, including 45.2% moderate, 54.8% severe, and 2.2% critical type patients. 69.9% of patients had at least one GI symptom; if excluding hyporexia/anorexia, 49.5% of patients showed at least one GI symptom. The incidence rate of hyporexia/anorexia, diarrhea, nausea/vomiting, abdominal discomfort/pain, and elevated liver enzymes were 67.7, 29.0, 28.0, 21.5, and 23.7%, respectively. Patients with GI symptoms or elevated liver enzymes have a higher risk of severe type disease than patients without GI symptoms or elevated liver enzymes (67.7 vs. 25.0%, p < 0.001; 77.3 vs. 47.9%, p = 0.016, respectively), and experienced longer disease duration. In multivariate analysis, hyporexia/anorexia was confirmed as an independent predictive factor of severe type disease (odds ratio: 5.912; 95% confidence interval: 2.247–15.559; p < 0.001). In conclusion, in the early stage of the COVID-19 pandemic, GI symptoms and elevated liver enzymes are common throughout the disease course, and associated with severer disease and longer disease duration. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630730/ /pubmed/36341271 http://dx.doi.org/10.3389/fmed.2022.997000 Text en Copyright © 2022 Chen, Ning, Feng and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Chen, Dafan Ning, Min Feng, Yun Liu, Jun The early stage of COVID-19 pandemic: Gastrointestinal manifestations and liver injury in COVID-19 patients in Wuhan, China |
title | The early stage of COVID-19 pandemic: Gastrointestinal manifestations and liver injury in COVID-19 patients in Wuhan, China |
title_full | The early stage of COVID-19 pandemic: Gastrointestinal manifestations and liver injury in COVID-19 patients in Wuhan, China |
title_fullStr | The early stage of COVID-19 pandemic: Gastrointestinal manifestations and liver injury in COVID-19 patients in Wuhan, China |
title_full_unstemmed | The early stage of COVID-19 pandemic: Gastrointestinal manifestations and liver injury in COVID-19 patients in Wuhan, China |
title_short | The early stage of COVID-19 pandemic: Gastrointestinal manifestations and liver injury in COVID-19 patients in Wuhan, China |
title_sort | early stage of covid-19 pandemic: gastrointestinal manifestations and liver injury in covid-19 patients in wuhan, china |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630730/ https://www.ncbi.nlm.nih.gov/pubmed/36341271 http://dx.doi.org/10.3389/fmed.2022.997000 |
work_keys_str_mv | AT chendafan theearlystageofcovid19pandemicgastrointestinalmanifestationsandliverinjuryincovid19patientsinwuhanchina AT ningmin theearlystageofcovid19pandemicgastrointestinalmanifestationsandliverinjuryincovid19patientsinwuhanchina AT fengyun theearlystageofcovid19pandemicgastrointestinalmanifestationsandliverinjuryincovid19patientsinwuhanchina AT liujun theearlystageofcovid19pandemicgastrointestinalmanifestationsandliverinjuryincovid19patientsinwuhanchina AT chendafan earlystageofcovid19pandemicgastrointestinalmanifestationsandliverinjuryincovid19patientsinwuhanchina AT ningmin earlystageofcovid19pandemicgastrointestinalmanifestationsandliverinjuryincovid19patientsinwuhanchina AT fengyun earlystageofcovid19pandemicgastrointestinalmanifestationsandliverinjuryincovid19patientsinwuhanchina AT liujun earlystageofcovid19pandemicgastrointestinalmanifestationsandliverinjuryincovid19patientsinwuhanchina |