Low perforin expression in CD8+ T lymphocytes during the acute phase of severe SARS-CoV-2 infection predicts long COVID

T cell cytotoxicity plays a major role in antiviral immunity. Anti-SARS-CoV-2 immunity may determine acute disease severity, but also the potential persistence of symptoms (long COVID). We therefore measured the expression of perforin, a cytotoxic mediator, in T cells of patients recently hospitaliz...

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Detalles Bibliográficos
Autores principales: Kundura, Lucy, Cezar, Renaud, André, Sonia, Campos-Mora, Mauricio, Lozano, Claire, Vincent, Thierry, Muller, Laurent, Lefrant, Jean-Yves, Roger, Claire, Claret, Pierre-Géraud, Duvnjak, Sandra, Loubet, Paul, Sotto, Albert, Tran, Tu-Ahn, Estaquier, Jérôme, Corbeau, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630742/
https://www.ncbi.nlm.nih.gov/pubmed/36341327
http://dx.doi.org/10.3389/fimmu.2022.1029006

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