Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability

Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in transcription, genome maintenance, and proteostasis. The contributions of many conserved secondary structures of Rad6 and its human homologs UBE2A and UBE2B to their biological functions are not understood. A mutan...

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Detalles Bibliográficos
Autores principales: Shukla, Prakash K., Sinha, Dhiraj, Leng, Andrew M., Bissell, Jesse E., Thatipamula, Shravya, Ganguly, Rajarshi, Radmall, Kaitlin S., Skalicky, Jack J., Shrieve, Dennis C., Chandrasekharan, Mahesh B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630792/
https://www.ncbi.nlm.nih.gov/pubmed/36162503
http://dx.doi.org/10.1016/j.jbc.2022.102524

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