Cargando…
Establishment and Evaluation of Dual HDAC/BET Inhibitors as Therapeutic Options for Germ Cell Tumors and Other Urological Malignancies
Urological malignancies represent major challenges for clinicians, with annually rising incidences. In addition, cisplatin treatment induced long-term toxicities and the development of therapy resistance emphasize the need for novel therapeutics. In this study, we analyzed the effects of novel histo...
Autores principales: | Burmeister, Aaron, Stephan, Alexa, Alves Avelar, Leandro A., Müller, Melanie R., Seiwert, Andrea, Höfmann, Stefan, Fischer, Fabian, Torres-Gomez, Hector, Hoffmann, Michèle J., Niegisch, Guenter, Bremmer, Felix, Petzsch, Patrick, Köhrer, Karl, Albers, Peter, Kurz, Thomas, Skowron, Margaretha A., Nettersheim, Daniel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630828/ https://www.ncbi.nlm.nih.gov/pubmed/35999659 http://dx.doi.org/10.1158/1535-7163.MCT-22-0207 |
Ejemplares similares
-
Combination of Ribociclib with BET-Bromodomain and PI3K/mTOR Inhibitors for Medulloblastoma Treatment In Vitro and In Vivo
por: Jonchere, Barbara, et al.
Publicado: (2023) -
Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights
por: Müller, Melanie R., et al.
Publicado: (2022) -
Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine Gliomas
por: Ehteda, Anahid, et al.
Publicado: (2023) -
Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death
por: Jenkins, Laura J., et al.
Publicado: (2023) -
Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death
por: Avelar, Rita A., et al.
Publicado: (2023)