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Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study

Cytomegalovirus (CMV) infection remains a critical cause of mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT), despite improvement by pre-emptive antivirus treatment. CMV-specific cytotoxic T lymphocytes (CMV-CTL) are universally used and proven well-tolerance after allo...

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Autores principales: Ruan, Yongsheng, Luo, Tingting, Liu, Qiujun, Liu, Xuan, Chen, Libai, Wen, Jianyun, Xiao, Yuhua, Xie, Danfeng, He, Yuelin, Wu, Xuedong, Feng, Xiaoqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630835/
https://www.ncbi.nlm.nih.gov/pubmed/36339340
http://dx.doi.org/10.3389/fcimb.2022.1027341
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author Ruan, Yongsheng
Luo, Tingting
Liu, Qiujun
Liu, Xuan
Chen, Libai
Wen, Jianyun
Xiao, Yuhua
Xie, Danfeng
He, Yuelin
Wu, Xuedong
Feng, Xiaoqin
author_facet Ruan, Yongsheng
Luo, Tingting
Liu, Qiujun
Liu, Xuan
Chen, Libai
Wen, Jianyun
Xiao, Yuhua
Xie, Danfeng
He, Yuelin
Wu, Xuedong
Feng, Xiaoqin
author_sort Ruan, Yongsheng
collection PubMed
description Cytomegalovirus (CMV) infection remains a critical cause of mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT), despite improvement by pre-emptive antivirus treatment. CMV-specific cytotoxic T lymphocytes (CMV-CTL) are universally used and proven well-tolerance after allo-HSCT in adult clinical trials. However, it is not comprehensively evaluated in children’s patients. Herein, we conducted a retrospective study to determine the risk factors of CMV infection and evaluation of CMV-CTL in children patients who underwent allo-HSCT. As result, a significantly poor 5-year overall survival was found in the CMV infection group (87.3 vs. 94.6%, p=0.01). Haploidentical HSCT (haplo-HSCT) was identified as an independent risk factor for CMV infection through both univariate and multivariate analyses (p<0.001, p=0.027, respectively). Furthermore, the cumulative incidence of CMV infection was statistically higher in the haplo-HSCT group compared to the HLA-matched donor group (44.2% vs. 21.6%, p<0.001). Finally, the overall response rate of CMV-CTL was 89.7% (26/29 patients) in CMV infection after allo-HSCT. We concluded that CMV infection following allo-HSCT correlated with increased mortality in children’s patients, and haplo-HSCT was an independent risk factor for CMV infection. Adoptive CMV-CTL cell therapy was safe and effective in pediatric patients with CMV infection.
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spelling pubmed-96308352022-11-04 Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study Ruan, Yongsheng Luo, Tingting Liu, Qiujun Liu, Xuan Chen, Libai Wen, Jianyun Xiao, Yuhua Xie, Danfeng He, Yuelin Wu, Xuedong Feng, Xiaoqin Front Cell Infect Microbiol Cellular and Infection Microbiology Cytomegalovirus (CMV) infection remains a critical cause of mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT), despite improvement by pre-emptive antivirus treatment. CMV-specific cytotoxic T lymphocytes (CMV-CTL) are universally used and proven well-tolerance after allo-HSCT in adult clinical trials. However, it is not comprehensively evaluated in children’s patients. Herein, we conducted a retrospective study to determine the risk factors of CMV infection and evaluation of CMV-CTL in children patients who underwent allo-HSCT. As result, a significantly poor 5-year overall survival was found in the CMV infection group (87.3 vs. 94.6%, p=0.01). Haploidentical HSCT (haplo-HSCT) was identified as an independent risk factor for CMV infection through both univariate and multivariate analyses (p<0.001, p=0.027, respectively). Furthermore, the cumulative incidence of CMV infection was statistically higher in the haplo-HSCT group compared to the HLA-matched donor group (44.2% vs. 21.6%, p<0.001). Finally, the overall response rate of CMV-CTL was 89.7% (26/29 patients) in CMV infection after allo-HSCT. We concluded that CMV infection following allo-HSCT correlated with increased mortality in children’s patients, and haplo-HSCT was an independent risk factor for CMV infection. Adoptive CMV-CTL cell therapy was safe and effective in pediatric patients with CMV infection. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9630835/ /pubmed/36339340 http://dx.doi.org/10.3389/fcimb.2022.1027341 Text en Copyright © 2022 Ruan, Luo, Liu, Liu, Chen, Wen, Xiao, Xie, He, Wu and Feng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Ruan, Yongsheng
Luo, Tingting
Liu, Qiujun
Liu, Xuan
Chen, Libai
Wen, Jianyun
Xiao, Yuhua
Xie, Danfeng
He, Yuelin
Wu, Xuedong
Feng, Xiaoqin
Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study
title Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study
title_full Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study
title_fullStr Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study
title_full_unstemmed Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study
title_short Features of cytomegalovirus infection and evaluation of cytomegalovirus-specific T cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: A retrospective single-center study
title_sort features of cytomegalovirus infection and evaluation of cytomegalovirus-specific t cells therapy in children’s patients following allogeneic hematopoietic stem cell transplantation: a retrospective single-center study
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9630835/
https://www.ncbi.nlm.nih.gov/pubmed/36339340
http://dx.doi.org/10.3389/fcimb.2022.1027341
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