BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022)

BNIP‐2 Activation of Cellular Contractility In article number 2202834 by Darren Chen Pei Wong, Pakorn Kanchanawong, Boon Chuan Low, and co‐workers, the multifaceted roles of the scaffold protein, BNIP‐2, are demonstrated to induce the expression of two cardiac markers, cTnT and Myl2, in H9c2 and hES...

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Detalles Bibliográficos
Autores principales: Wong, Darren Chen Pei, Xiao, Jingwei, Chew, Ti Weng, Pan, Meng, Lee, Chang Jie Mick, Ang, Jing Wen, Yow, Ivan, Thivakar, T., Ackers‐Johnson, Matthew, Lee, Nicole Jia Wen, Foo, Roger Sik‐Yin, Kanchanawong, Pakorn, Low, Boon Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631054/
http://dx.doi.org/10.1002/advs.202270197
Descripción
Sumario:BNIP‐2 Activation of Cellular Contractility In article number 2202834 by Darren Chen Pei Wong, Pakorn Kanchanawong, Boon Chuan Low, and co‐workers, the multifaceted roles of the scaffold protein, BNIP‐2, are demonstrated to induce the expression of two cardiac markers, cTnT and Myl2, in H9c2 and hESC cells. During this process, BNIP‐2 activation of contractility and scaffolding of LATS1 to Yes‐associated protein (YAP) is required to inactivate YAP for cardiomyoblast differentiation. [Image: see text]

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