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BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022)
BNIP‐2 Activation of Cellular Contractility In article number 2202834 by Darren Chen Pei Wong, Pakorn Kanchanawong, Boon Chuan Low, and co‐workers, the multifaceted roles of the scaffold protein, BNIP‐2, are demonstrated to induce the expression of two cardiac markers, cTnT and Myl2, in H9c2 and hES...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631054/ http://dx.doi.org/10.1002/advs.202270197 |
| _version_ | 1784823736488165376 |
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| author | Wong, Darren Chen Pei Xiao, Jingwei Chew, Ti Weng Pan, Meng Lee, Chang Jie Mick Ang, Jing Wen Yow, Ivan Thivakar, T. Ackers‐Johnson, Matthew Lee, Nicole Jia Wen Foo, Roger Sik‐Yin Kanchanawong, Pakorn Low, Boon Chuan |
| author_facet | Wong, Darren Chen Pei Xiao, Jingwei Chew, Ti Weng Pan, Meng Lee, Chang Jie Mick Ang, Jing Wen Yow, Ivan Thivakar, T. Ackers‐Johnson, Matthew Lee, Nicole Jia Wen Foo, Roger Sik‐Yin Kanchanawong, Pakorn Low, Boon Chuan |
| author_sort | Wong, Darren Chen Pei |
| collection | PubMed |
| description | BNIP‐2 Activation of Cellular Contractility In article number 2202834 by Darren Chen Pei Wong, Pakorn Kanchanawong, Boon Chuan Low, and co‐workers, the multifaceted roles of the scaffold protein, BNIP‐2, are demonstrated to induce the expression of two cardiac markers, cTnT and Myl2, in H9c2 and hESC cells. During this process, BNIP‐2 activation of contractility and scaffolding of LATS1 to Yes‐associated protein (YAP) is required to inactivate YAP for cardiomyoblast differentiation. [Image: see text] |
| format | Online Article Text |
| id | pubmed-9631054 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96310542022-11-07 BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022) Wong, Darren Chen Pei Xiao, Jingwei Chew, Ti Weng Pan, Meng Lee, Chang Jie Mick Ang, Jing Wen Yow, Ivan Thivakar, T. Ackers‐Johnson, Matthew Lee, Nicole Jia Wen Foo, Roger Sik‐Yin Kanchanawong, Pakorn Low, Boon Chuan Adv Sci (Weinh) Inside Front Cover BNIP‐2 Activation of Cellular Contractility In article number 2202834 by Darren Chen Pei Wong, Pakorn Kanchanawong, Boon Chuan Low, and co‐workers, the multifaceted roles of the scaffold protein, BNIP‐2, are demonstrated to induce the expression of two cardiac markers, cTnT and Myl2, in H9c2 and hESC cells. During this process, BNIP‐2 activation of contractility and scaffolding of LATS1 to Yes‐associated protein (YAP) is required to inactivate YAP for cardiomyoblast differentiation. [Image: see text] John Wiley and Sons Inc. 2022-11-03 /pmc/articles/PMC9631054/ http://dx.doi.org/10.1002/advs.202270197 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Inside Front Cover Wong, Darren Chen Pei Xiao, Jingwei Chew, Ti Weng Pan, Meng Lee, Chang Jie Mick Ang, Jing Wen Yow, Ivan Thivakar, T. Ackers‐Johnson, Matthew Lee, Nicole Jia Wen Foo, Roger Sik‐Yin Kanchanawong, Pakorn Low, Boon Chuan BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022) |
| title | BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022) |
| title_full | BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022) |
| title_fullStr | BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022) |
| title_full_unstemmed | BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022) |
| title_short | BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022) |
| title_sort | bnip‐2 activation of cellular contractility inactivates yap for h9c2 cardiomyoblast differentiation (adv. sci. 31/2022) |
| topic | Inside Front Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631054/ http://dx.doi.org/10.1002/advs.202270197 |
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