Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022)

Mechanism of Synthetic Retinoid Kills Cancer‐Stem‐Cell‐Like Cells In article number 2203173, Xing Cao, Ning Wang, Junwei Chen, and co‐workers reveal the mechanism of synthetic retinoid WYC‐209 overcomes the limitation of conventional anticancer drugs by inducing tension‐abrogation mediated chromatin...

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Detalles Bibliográficos
Autores principales: Zhang, Yao, Dong, Qi, An, Quanlin, Zhang, Chumei, Mohagheghian, Erfan, Niu, Bing, Qi, Feng, Wei, Fuxiang, Chen, Sihan, Chen, Xinman, Wang, Anqi, Cao, Xin, Wang, Ning, Chen, Junwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631085/
http://dx.doi.org/10.1002/advs.202270202
Descripción
Sumario:Mechanism of Synthetic Retinoid Kills Cancer‐Stem‐Cell‐Like Cells In article number 2203173, Xing Cao, Ning Wang, Junwei Chen, and co‐workers reveal the mechanism of synthetic retinoid WYC‐209 overcomes the limitation of conventional anticancer drugs by inducing tension‐abrogation mediated chromatin decondensation and DNA damage to kill cancer‐stem‐cell‐like cell tumor repopulating cells. This finding provides a new perspective strategy of lowering cell tension and decondensing chromatin to enhance efficacy of anti‐cancer drugs to abrogate metastasis of cancer stem cell like cells. [Image: see text]

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