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Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022)
Mechanism of Synthetic Retinoid Kills Cancer‐Stem‐Cell‐Like Cells In article number 2203173, Xing Cao, Ning Wang, Junwei Chen, and co‐workers reveal the mechanism of synthetic retinoid WYC‐209 overcomes the limitation of conventional anticancer drugs by inducing tension‐abrogation mediated chromatin...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631085/ http://dx.doi.org/10.1002/advs.202270202 |
| _version_ | 1784823745276280832 |
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| author | Zhang, Yao Dong, Qi An, Quanlin Zhang, Chumei Mohagheghian, Erfan Niu, Bing Qi, Feng Wei, Fuxiang Chen, Sihan Chen, Xinman Wang, Anqi Cao, Xin Wang, Ning Chen, Junwei |
| author_facet | Zhang, Yao Dong, Qi An, Quanlin Zhang, Chumei Mohagheghian, Erfan Niu, Bing Qi, Feng Wei, Fuxiang Chen, Sihan Chen, Xinman Wang, Anqi Cao, Xin Wang, Ning Chen, Junwei |
| author_sort | Zhang, Yao |
| collection | PubMed |
| description | Mechanism of Synthetic Retinoid Kills Cancer‐Stem‐Cell‐Like Cells In article number 2203173, Xing Cao, Ning Wang, Junwei Chen, and co‐workers reveal the mechanism of synthetic retinoid WYC‐209 overcomes the limitation of conventional anticancer drugs by inducing tension‐abrogation mediated chromatin decondensation and DNA damage to kill cancer‐stem‐cell‐like cell tumor repopulating cells. This finding provides a new perspective strategy of lowering cell tension and decondensing chromatin to enhance efficacy of anti‐cancer drugs to abrogate metastasis of cancer stem cell like cells. [Image: see text] |
| format | Online Article Text |
| id | pubmed-9631085 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96310852022-11-07 Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022) Zhang, Yao Dong, Qi An, Quanlin Zhang, Chumei Mohagheghian, Erfan Niu, Bing Qi, Feng Wei, Fuxiang Chen, Sihan Chen, Xinman Wang, Anqi Cao, Xin Wang, Ning Chen, Junwei Adv Sci (Weinh) Inside Back Cover Mechanism of Synthetic Retinoid Kills Cancer‐Stem‐Cell‐Like Cells In article number 2203173, Xing Cao, Ning Wang, Junwei Chen, and co‐workers reveal the mechanism of synthetic retinoid WYC‐209 overcomes the limitation of conventional anticancer drugs by inducing tension‐abrogation mediated chromatin decondensation and DNA damage to kill cancer‐stem‐cell‐like cell tumor repopulating cells. This finding provides a new perspective strategy of lowering cell tension and decondensing chromatin to enhance efficacy of anti‐cancer drugs to abrogate metastasis of cancer stem cell like cells. [Image: see text] John Wiley and Sons Inc. 2022-11-03 /pmc/articles/PMC9631085/ http://dx.doi.org/10.1002/advs.202270202 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Inside Back Cover Zhang, Yao Dong, Qi An, Quanlin Zhang, Chumei Mohagheghian, Erfan Niu, Bing Qi, Feng Wei, Fuxiang Chen, Sihan Chen, Xinman Wang, Anqi Cao, Xin Wang, Ning Chen, Junwei Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022) |
| title | Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022) |
| title_full | Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022) |
| title_fullStr | Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022) |
| title_full_unstemmed | Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022) |
| title_short | Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation (Adv. Sci. 31/2022) |
| title_sort | synthetic retinoid kills drug‐resistant cancer stem cells via inducing rarγ‐translocation‐mediated tension reduction and chromatin decondensation (adv. sci. 31/2022) |
| topic | Inside Back Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631085/ http://dx.doi.org/10.1002/advs.202270202 |
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